T1-weighted imaging – analysis pipeline and initial volumetric results. A. Schematic figure representing the pipeline set up to analyse T1-weighted images. The (A) raw T1-weighted image is initially (B) pre-processed (bias field corrected, neck cropped and brain extracted). Subsequently, (C) brain tissues are segmented into gray matter (GM, red), white matter (WM, blue) and cerebrospinal fluid (CSF, green). Finally, (D) subcortical brain regions are segmented. R and L define the right and the left hemisphere, respectively. B. Histogram of hippocampal sizes in the first 300 participants. Volume measures in 10-3 ml.