Association of TPH-1 and TPH-2 gene polymorphisms with suicidal behavior: a systematic review and meta-analysis

González-Castro, Thelma Beatriz; Juárez-Rojop, Isela; López-Narváez, María Lilia; Tovilla-Zárate, Carlos Alfonso

doi:10.1186/1471-244X-14-196

BMC Psychiatry

Table 1 Descriptive characteristics in association studies on A218C/A779C TPH-1 gene variants and SB by populations

From: Association of TPH-1 and TPH-2 gene polymorphisms with suicidal behavior: a systematic review and meta-analysis

Reference	Location	Diagnosis	Number of males		Number		Genotypes		Alleles		P for HWE
Reference	Location	Diagnosis	Cases	Controls	Cases	Controls	Cases	Controls	Cases	Controls	Cases	Controls
							AA/AC/CC	AA/AC/CC	A/C	A/C
*Caucasian population (A218C TPH-1 variant)*
Bellivier F. et al., 1998 [62]	France	SA and manic-depression	-	57	104	94	34/48/22	11/45/38	116/92	67/121	0.08	0.55
Geijer T. et al., 2000 [53]	Sweden	SA	57	64	165	98	30/87/48	13/47/38	147/183	73/123	1.00	0.43
Du L. et al., 2000 [54]	Canada	SC	-	-	35	84	6/24/5	13/52/19	36/34	78/90	0.04*	0.04*
Souery D. et al., 2001 [37]	Germany, Greece, Israel, Italy, Sweden, UK.	SI and bipolar disorder	-	-	167	167	29/85/53	27/74/66	143/191	128/206	0.41	0.75
Abbar M. et al., 2001 [47]	France	SA	105	170	231	281	43/120/68	30/133/118	206/256	193/369	0.50	0.30
Zalsman G.et al., 2001 [40]	Israel	SA	40	74	84	172	16/34/34	41/85/46	66/102	167/178	0.89	0.17
Turecki G. et al., 2001 [39]	Canada	SC	-	-	101	129	18/48/35	18/71/40	84/118	107/151	0.15	0.83
Rujescu D. et al., 2002 [36]	Germany	SA and anger related traits	27	66	86	154	10/48/28	19/78/57	68/104	116/192	0.39	0.17
Rujescu D. et al., 2003 [24]	Germany	SA	52	-	147	326	18/81/48	40/155/131	117/177	235/417	0.63	0.08
Jernej B. et al., 2004 [34]	Croatia	SC	144	298	185	358	84/85/16	202/141/15	253/117	545/171	0.14	0.49
Stefulj J. et al., 2005 [16]	Croatia	SC	160	284	160	284	21/69/70	44/145/95	111/209	233/335	0.39	0.60
Stefulj J. et al., 2006 [46]	Croatia	SC	247	320	247	320	33/111/103	50/162/108	177/317	262/378	0.48	0.78
Viana M.M. et al., 2006 [48]	Brazil	SA, major depression, schizophrenia and alcoholism	142	36	248	63	45/125/78	7/31/25	215/281	45/81	0.78	0.79
Baud P. et al., 2009 [28]	Switzerland, France	SA	166	-	537	1027	99/256/182	181/483/363	454/260	845/1209	0.59	0.34
Wilson T.et al., 2009 [52]	USA	SA and bipolar disorder	-	39	71	101	13/44/14	22/43/36	70/72	87/115	0.22	0.05*
Saetre P. et al., 2010 [23]	Denmark, Norway, Sweden	SA and schizophrenia	-	845	825	1460	289/391/145	570/694/196	969/681	1834/1086	0.00*	0.63
Buttenschon H.N. et al., 2013 [41]	Denmark	SC	209	763	490	1027	80/228/182	181/843/363	388/592	845/1209	0.36	0.57
							868/1884/1131	1469/3282/1754			0.11	0.37
*Asian population (A218C TPH-1 variant)*
Tsai S.J. et al., 1999 [55]	Taiwan	SA and mood disorders	-	-	41	200	17/15/9	33/113/54	49/33	179/221	0.06	0.19
Liu X. et al., 2006 [56]	China	SA	171	98	287	177	72/148/67	41/84/49	292/282	166/182	0.65	0.63
Yoon H.K. et al., 2008 [44]	Korea	SA and major depression	70	73	193	191	49/97/45	60/85/48	195/187	205/181	0.11	0.88
Kunugi H. et al.,1999 [42]	Japan	SA	-	95	46	208	10/29/7	55/105/48	49/43	215/201	1.00	0.13
Paik I. et al., 2000 [45]	Korea	SA and schizophrenia	-	124	27	236	04/12/11	66/116/54	20/34	248/224	0.89	1.00
Ono H., et al., 2000 [43]	Japan	SC	90	90	132	132	29/68/35	26/71/35	126/138	123/141	0.38	0.86
Hong C.J. et al., 2001 [35]	Taiwan	SA and schizophrenia	-	123	140	251	42/57/41	42/135/74	141/139	219/283	0.15	0.02*
Ohtani M. et al., 2004 [49]	Japan	SC	95	171	134	325	30/60/42	44/113/57	120/144	201/227	0.41	0.37
							253/486/257	367/822/419
*Caucasian population (A779C TPH-1 variant)*
Nielsen D.A. et al.,1998 [38]	USA	SI and alcoholism	-	232	102	232	17/57/28	49/106/77	91/113	204/260	0.28	0.23
Rotondo A. et al., 1999 [51]	Italy and USA	SA	-	153	97	153	12/50/35	33/68/52	74/120	215/201	0.25	0.51
Roy A. et al., 2001 [17]	Sweden	SC	-	-	24	158	02/12/20	35/86/37	16/332	156/160	0.33	1.00
Saetre P. et al., 2010 [23]	Denmark, Norway and Sweden	SA and schizophrenia	-	845	830	1464	290/391/149	570/691/203	971/689	1831/1097	0.00*	0.63
Pooley E.C. et al., 2003 [50]	UK	SA	52	138	129	329	20/67/42	44/135/150	107/151	223/435	0.13	0.47
							341/577/274	731/1086/519			0.44	0.34
*Asian population (A779C TPH-1 variant)*
Kunugi H. et al., 1999 [42]	Japan	SA	-	95	46	208	10/29/7	55/105/48	49/43	215/201	1.00	0.13
Ohtani M. et al., 2004 [49]	Japan	SC	95	171	134	325	30/59/42	45/138/82	119/143	228/302	0.38	0.29
Liu X., et al. 2006 [56]	China	SA	171	98	266	164	77/126/63	43/85/36	280/252	171/157	0.75	0.46
							117/214/112	143/328/166			0.50	0.47

SA = Suicide attempt, SI = Suicide ideation, and SC = Suicide completion.* Non equilibrium of Hardy Weinberg.

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