Sleep parameter | Placebo | Olanzapine | |||||
---|---|---|---|---|---|---|---|
 | Baseline | Day 2-4 | Day 28-31 | Baseline | Day 2-4 | Day 28-31 | ANOVA |
 | Mean ± SD | Mean ± SD | |||||
Sleep continuity | Â | Â | Â | Â | Â | Â | Â |
Total time in bed (min) | 468 ± 27 | 454 ± 37 | 458 ± 30 | 460 ± 41 | 457 ± 32 | 461 ± 32 | p = .523 |
Total sleep time (min) | 315 ± 62 | 307 ± 58 | 289 ± 75 | 326 ± 168 | 383 ± 66 | 363 ± 89 | p = .043 |
Total wake time (min) | 153 ± 67 | 148 ± 63 | 169 ± 75 | 135 ± 107 | 74 ± 68 | 80 ± 63 | p = .023 |
No. of awakenings | 29 ± 18 | 23 ± 9 | 26 ± 11 | 18 ± 7.0 | 13 ± 4.9 | 15 ± 7.1 | p = .775 |
No. of stage changes | 145 ± 77 | 125 ± 50 | 123 ± 50 | 99 ± 36 | 101 ± 44 | 98 ± 38 | p = .254 |
Respiratory disturbance index | 15 ± 14 | 13 ± 12 | 8.7 ± 7.2 | 13 ± 21 | 11 ± 25 | 12 ± 25 | p = .126 |
Sleep efficiency | 67 ± 14 | 68 ± 14 | 63 ± 17 | 71 ± 23 | 84 ± 14 | 83 ± 13 | p = .031 |
Sleep architecture | Â | Â | Â | Â | Â | Â | Â |
Latency to sleep (min) | 76 ± 61 | 86 ± 67 | 92 ± 78 | 69 ± 83 | 38 ± 50 | 41 ± 45 | p = 0.069 |
Latency to Stage 1 (min) | 67 ± 54 | 73 ± 51 | 85 ± 77 | 72 ± 74 | 42 ± 42 | 45 ± 41 | p = .073 |
Duration of Stage 1 (min) | 36 ± 28 | 30 ± 16 | 31 ± 16 | 32 ± 18 | 25 ± 12 | 27 ± 10 | p = .984 |
Duration of Stage 1 (% of TST) | 11 ± 8.0 | 10 ± 4.5 | 11 ± 5.0 | 11 ± 11 | 6.5 ± 2.8 | 7.2 ± 3.5 | p = .353 |
Latency to Stage 2 (min) | 82 ± 68 | 92 ± 72 | 96 ± 81 | 79 ± 86 | 46 ± 59 | 47 ± 49 | p = .058 |
Duration of Stage 2 (min) | 168 ± 62 | 160 ± 62 | 166 ± 58 | 199.3 ± 69.3 | 230.7 ± 55.4 | 230 ± 55 | p = .048 |
Duration of Stage 2 (% of TST) | 53 ± 13 | 51 ± 12 | 56 ± 12 | 57 ± 12 | 60 ± 12 | 60 ± 10 | p = .927 |
Latency to R (min) | 212 ± 88 | 220 ± 89 | 277 ± 250 | 165 ± 132 | 184 ± 100 | 180 ± 97 | p = .552 |
Duration of R (min) | 59 ± 20 | 66 ± 27 | 48 ± 28 | 77 ± 50 | 82 ± 37 | 87 ± 39 | p = .285 |
Duration of R (% of TST) | 19 ± 5.9 | 22 ± 7.8 | 16 ± 7.5 | 20 ± 12 | 21 ± 7.7 | 22 ± 8.4 | p = .239 |
Latency to SWS (min) | 112 ± 75 | 116 ± 14 | 172 ± 124 | 121 ± 122 | 59 ± 64 | 77 ± 70 | p = .028 |
Duration of SWS (min) | 48 ± 34 | 47 ± 31 | 43 ± 27 | 28 ± 25 | 44 ± 48 | 38 ± 43 | p = .295 |
Duration of SWS (% of TST) | 17 ± 13 | 18 ± 13 | 17 ± 14 | 10 ± 12 | 12 ± 12 | 10 ± 12 | p = .994 |