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Table 2 Polysomnographic measures

From: Sleep architecture and cognitive changes in olanzapine-treated patients with depression: A double blind randomized placebo controlled trial

Sleep parameter

Placebo

Olanzapine

 

Baseline

Day 2-4

Day 28-31

Baseline

Day 2-4

Day 28-31

ANOVA

 

Mean ± SD

Mean ± SD

Sleep continuity

       

Total time in bed (min)

468 ± 27

454 ± 37

458 ± 30

460 ± 41

457 ± 32

461 ± 32

p = .523

Total sleep time (min)

315 ± 62

307 ± 58

289 ± 75

326 ± 168

383 ± 66

363 ± 89

p = .043

Total wake time (min)

153 ± 67

148 ± 63

169 ± 75

135 ± 107

74 ± 68

80 ± 63

p = .023

No. of awakenings

29 ± 18

23 ± 9

26 ± 11

18 ± 7.0

13 ± 4.9

15 ± 7.1

p = .775

No. of stage changes

145 ± 77

125 ± 50

123 ± 50

99 ± 36

101 ± 44

98 ± 38

p = .254

Respiratory disturbance index

15 ± 14

13 ± 12

8.7 ± 7.2

13 ± 21

11 ± 25

12 ± 25

p = .126

Sleep efficiency

67 ± 14

68 ± 14

63 ± 17

71 ± 23

84 ± 14

83 ± 13

p = .031

Sleep architecture

       

Latency to sleep (min)

76 ± 61

86 ± 67

92 ± 78

69 ± 83

38 ± 50

41 ± 45

p = 0.069

Latency to Stage 1 (min)

67 ± 54

73 ± 51

85 ± 77

72 ± 74

42 ± 42

45 ± 41

p = .073

Duration of Stage 1 (min)

36 ± 28

30 ± 16

31 ± 16

32 ± 18

25 ± 12

27 ± 10

p = .984

Duration of Stage 1 (% of TST)

11 ± 8.0

10 ± 4.5

11 ± 5.0

11 ± 11

6.5 ± 2.8

7.2 ± 3.5

p = .353

Latency to Stage 2 (min)

82 ± 68

92 ± 72

96 ± 81

79 ± 86

46 ± 59

47 ± 49

p = .058

Duration of Stage 2 (min)

168 ± 62

160 ± 62

166 ± 58

199.3 ± 69.3

230.7 ± 55.4

230 ± 55

p = .048

Duration of Stage 2 (% of TST)

53 ± 13

51 ± 12

56 ± 12

57 ± 12

60 ± 12

60 ± 10

p = .927

Latency to R (min)

212 ± 88

220 ± 89

277 ± 250

165 ± 132

184 ± 100

180 ± 97

p = .552

Duration of R (min)

59 ± 20

66 ± 27

48 ± 28

77 ± 50

82 ± 37

87 ± 39

p = .285

Duration of R (% of TST)

19 ± 5.9

22 ± 7.8

16 ± 7.5

20 ± 12

21 ± 7.7

22 ± 8.4

p = .239

Latency to SWS (min)

112 ± 75

116 ± 14

172 ± 124

121 ± 122

59 ± 64

77 ± 70

p = .028

Duration of SWS (min)

48 ± 34

47 ± 31

43 ± 27

28 ± 25

44 ± 48

38 ± 43

p = .295

Duration of SWS (% of TST)

17 ± 13

18 ± 13

17 ± 14

10 ± 12

12 ± 12

10 ± 12

p = .994

  1. The mean ± standard deviation (SD) of sleep parameters for both olanzapine and placebo treated group. TST = Total Sleep Time, SWS = Slow Wave Sleep, REM = Rapid Eye Movement. P value reported for the interaction (time by treatment) of a two-way repeated measures ANOVA.