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Table 2 Polysomnographic measures

From: Sleep architecture and cognitive changes in olanzapine-treated patients with depression: A double blind randomized placebo controlled trial

Sleep parameter Placebo Olanzapine
  Baseline Day 2-4 Day 28-31 Baseline Day 2-4 Day 28-31 ANOVA
  Mean ± SD Mean ± SD
Sleep continuity        
Total time in bed (min) 468 ± 27 454 ± 37 458 ± 30 460 ± 41 457 ± 32 461 ± 32 p = .523
Total sleep time (min) 315 ± 62 307 ± 58 289 ± 75 326 ± 168 383 ± 66 363 ± 89 p = .043
Total wake time (min) 153 ± 67 148 ± 63 169 ± 75 135 ± 107 74 ± 68 80 ± 63 p = .023
No. of awakenings 29 ± 18 23 ± 9 26 ± 11 18 ± 7.0 13 ± 4.9 15 ± 7.1 p = .775
No. of stage changes 145 ± 77 125 ± 50 123 ± 50 99 ± 36 101 ± 44 98 ± 38 p = .254
Respiratory disturbance index 15 ± 14 13 ± 12 8.7 ± 7.2 13 ± 21 11 ± 25 12 ± 25 p = .126
Sleep efficiency 67 ± 14 68 ± 14 63 ± 17 71 ± 23 84 ± 14 83 ± 13 p = .031
Sleep architecture        
Latency to sleep (min) 76 ± 61 86 ± 67 92 ± 78 69 ± 83 38 ± 50 41 ± 45 p = 0.069
Latency to Stage 1 (min) 67 ± 54 73 ± 51 85 ± 77 72 ± 74 42 ± 42 45 ± 41 p = .073
Duration of Stage 1 (min) 36 ± 28 30 ± 16 31 ± 16 32 ± 18 25 ± 12 27 ± 10 p = .984
Duration of Stage 1 (% of TST) 11 ± 8.0 10 ± 4.5 11 ± 5.0 11 ± 11 6.5 ± 2.8 7.2 ± 3.5 p = .353
Latency to Stage 2 (min) 82 ± 68 92 ± 72 96 ± 81 79 ± 86 46 ± 59 47 ± 49 p = .058
Duration of Stage 2 (min) 168 ± 62 160 ± 62 166 ± 58 199.3 ± 69.3 230.7 ± 55.4 230 ± 55 p = .048
Duration of Stage 2 (% of TST) 53 ± 13 51 ± 12 56 ± 12 57 ± 12 60 ± 12 60 ± 10 p = .927
Latency to R (min) 212 ± 88 220 ± 89 277 ± 250 165 ± 132 184 ± 100 180 ± 97 p = .552
Duration of R (min) 59 ± 20 66 ± 27 48 ± 28 77 ± 50 82 ± 37 87 ± 39 p = .285
Duration of R (% of TST) 19 ± 5.9 22 ± 7.8 16 ± 7.5 20 ± 12 21 ± 7.7 22 ± 8.4 p = .239
Latency to SWS (min) 112 ± 75 116 ± 14 172 ± 124 121 ± 122 59 ± 64 77 ± 70 p = .028
Duration of SWS (min) 48 ± 34 47 ± 31 43 ± 27 28 ± 25 44 ± 48 38 ± 43 p = .295
Duration of SWS (% of TST) 17 ± 13 18 ± 13 17 ± 14 10 ± 12 12 ± 12 10 ± 12 p = .994
  1. The mean ± standard deviation (SD) of sleep parameters for both olanzapine and placebo treated group. TST = Total Sleep Time, SWS = Slow Wave Sleep, REM = Rapid Eye Movement. P value reported for the interaction (time by treatment) of a two-way repeated measures ANOVA.