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Table 3 Clinical measures

From: Sleep architecture and cognitive changes in olanzapine-treated patients with depression: A double blind randomized placebo controlled trial

 Clinical measures Placebo Olanzapine
Baseline Day 2-4 Day 28-31 Baseline Day 2-4 Day 28-31 ANOVA
Mean ± SD Mean ± SD
MADRS total 26 ± 6.3 26 ± 7.1 24 ± 3.2 25 ± 5.8 23 ± 6.2 19 ± 11 p = .175
HDRS total 21 ± 5.5 19 ± 5.9 18 ± 7.4 22 ± 5.0 18 ± 6.4 15 ± 8.4 p = .123
HARS total 16 ± 2.9 13 ± 4.7 13 ± 5.3 17 ± 5.8 15 ± 7.4 13 ± 6.7 p = .420
YMRS total 3.9 ± 3.4 3.7 ± 2.5 4.7 ± 4.2 3.7 ± 3.1 2.9 ± 3.0 3.5 ± 2.3 p = .223
PSQI total 13 ± 3.0 14 ± 3.6 12 ± 5.2 12 ± 3.5 11 ± 4.2 9.9 ± 4.7 p = .699
VAS total 31 ± 15 32 ± 19 43 ± 27 37 ± 27 45 ± 28 59 ± 30 p = .415
ESS total 7.4 ± 6.2 5.4 ± 4.2 5.8 ± 5.9 8.4 ± 5.2 8.5 ± 5.6 7.3 ± 5.2 p = .666
  1. The mean ± standard deviation (SD) of selected clinical measures for both olanzapine and placebo treated group. MADRS = Montgomery Asberg Depression Rating Scale, HDRS = Hamilton Depression Rating Scale, HARS = Hamilton Anxiety Rating Scale, YMRS = Young Mania Rating Scale, VAS = Visual Analogue Scale for sleep quality, PSQI = Pittsburg Sleep Quality Index, ESS = Epworth Sleepiness Scale. P value reported for the interaction (time by treatment) of a two-way repeated measures ANOVA.