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Table 2 Clinical Characteristic Comparisons by BDI-II Depression and PSQI Sleep Disturbance Groups

From: Sleep disturbance, depression and pain in adults with sickle cell disease

Demographic Variables BDI < 17 BDI ≥ 17 p 1 PSQI < 6 PSQI ≥ 6 p 1
  N Median (IQR) 2 N Median (IQR) 2   N Median (IQR) 2 N Median (IQR) 2  
Age 250 34 (27–47) 65 35 (27–45) .95 90 31 (23–45) 223 36 (29–47) .009
BMI (kg/m2) 245 24 (22–27) 63 24 (21–27) .12 89 23 (20–27) 217 24 (22–28) .016
Female, N (%) 250 119 (48) 65 40 (62) .052 90 42 (47) 223 118 (53) .32
SS/Sβ0 thalassemia, N (%) 250 212 (85) 65 53 (82) .57 90 78 (87) 223 184 (83) .40
Clinical History           
Headache, N (%) 250 92 (37) 64 36 (53) .007 90 24 (27) 222 105 (47) <.001
Stroke, N (%) 230 32 (14) 56 6 (11) .66 81 14 (17) 204 23 (11) .18
Acute Chest Syndrome, N (%) 248 201 (81) 65 52 (80) .86 90 70 (78) 223 184 (83) .34
Hydroxyurea therapy, N (%) 250 120 (48) 65 31 (48) >.99 90 42 (47) 223 106 (48) .90
Mild + Moderate Pain (days) 244 11 (2–72) 60 25 (4–126) .040 88 4 (2–24) 214 23 (4–120) <.001
Severe + Extreme Pain (events) 250 2 (0–5) 65 3 (0–10) .009 90 0 (0–2) 223 3 (0–9) <.001
Current Narcotic Use, N (%) 250 159 (64) 65 47 (72) .24 90 53 (59) 223 153 (69) .11
Laboratory Measures           
Hemoglobin (g/dL) 250 9.1 (7.8-10.4) 65 8.5 (7.4-9.8) .050 90 9.3 (8.1-10.4) 223 8.9 (7.6-10.3) .20
Hemoglobin F (%) 250 5.7 (1.9-12.5) 65 6.0 (3.1-10.7) .97 90 5.1 (1.8-13.2) 223 6.0 (2.7-11.7) .76
Oxygen Saturation (%) 248 97 (95–99) 65 97 (95–99) .97 89 98 (96–99) 222 97 (95–99) .093
  1. 1Pearson’s chi-square or Fisher’s exact test for categorical comparisons; Wilcoxon rank-sum for comparison of medians.
  2. 2Unless otherwise indicated.