Larcombe (1984) [48]
|
BDI ≥ 20; Self-reported depression ≥ 3 months; Met Feighner criteria for ‘definite’ or ‘probable’ depression; No psychological co-morbidities; Low suicide risk; Normal memory function; No concurrent or prior treatment with major tranquilisers or lithium. Diagnosis of MS confirmed by a neurologist
|
Six weekly 90 minute group cognitive behavioural therapy sessions
|
Waiting list for delayed treatment
|
BDI; HRSD; Mood Ratings (3 item questionnaire, 10 point scale); Depression as rated by significant other (6 item questionnaire, 4 point scale)
|
Mohr (2001) [25]
|
BDI ≥ 16; HRSD ≥ 16; Clinical diagnosis of MDD assessed using SCID; No psychological or neurological co-morbidities, suicidal tendencies or CNS disorders; Willingness to abstain from any other treatment for depression than that provided in the study. Confirmed diagnosis of MS (Poser criteria)
|
Sixteen weekly 50 minute individually administered cognitive behavioural therapy sessions
|
Supportive-expressive group therapy; Sertraline
|
BDI; BDI-18; HRSD; MDD assessed using SCID
|
Mohr (2005) [47]
|
BDI-II ≥ 16; HRSD ≥ 14; GNDS ≥ 3 on one or more areas of functioning; No co-morbid dementia, psychosis, substance abuse or suicidal tendencies; Not currently undergoing psychotherapy; No medication other than antidepressants. Diagnosis of MS confirmed by a neurologist
|
Sixteen weekly 50 minute telephone administered cognitive behavioural therapy sessions
|
Telephone administered supportive emotion-focused therapy
|
BDI-II; HRSD; MDD assessed using SCID; Positive affect measured using PANAS-PA
|
Mohr (2000) [45]
|
POMS-DS ≥ 15; If in treatment for depression must have been in that treatment for ≥ 3 months; No co-morbid dementia or neurological disorders. Confirmed diagnosis of MS (Poser criteria)
|
Eight weekly 50 minute telephone administered cognitive behavioural therapy sessions
|
Standard care
|
POMS-DS; Post-treatment adherence to IFNβ-1a
|
Forman (2010) [43]
|
Diagnosis of MS > 3 months; HADS ≥ 8 or GHQ-12 ≥ 3
|
Six fortnightly 120 minute group therapy sessions based on cognitive-behavioural and psycho-educational framework
|
Standard care
|
HADS; GHQ-12; MSIS; MSSE; SF-36
|
Lincoln (2011) [44]
|
Diagnosis of MS > 12 months; HADS ≥ 8 or GHQ-12 ≥ 3. Diagnosis of MS confirmed by a neurologist
|
Six fortnightly 120 minute group therapy sessions based on cognitive-behavioural and psycho-educational framework
|
Standard care
|
BDI-II; HADS; GHQ-12; MSIS; MSSE; EQ-5D
|
Cooper (2011) [30]
|
BDI-II ≥ 14 but < 29; EDSS < 8.5; MMSE < 24; No psychological co-morbidities; Low suicide risk; No treatment from psychologist, psychotherapist or psychiatrist within last 3 months. Confirmed diagnosis of MS (McDonald criteria)
|
Eight 50 minute computerised cognitive behavioural therapy sessions
|
Standard care
|
BDI-II; MSIS; SF-36; PHQ-9; GAD-7
|