Table 1 LUNSERS scores (mean ± SD) and frequency of side effects according to genotype and in the total population
From: CYP1A2polymorphism −1545C > T (rs2470890) is associated with increased side effects to clozapine
Symptom | LUNSERS scores mean (±SD) | |||
|---|---|---|---|---|
Frequency of the symptom % | ||||
TT (n=54) | TC (n=96) | CC (n=35) | Total (n=185) | |
Sympathicotonia-tension | 7.35 (±4.87) | 6.54 (±4.77) | 6.69 (±5.61) | 6.81 (±4.95) |
88.9% | 92.7% | 82.9% | 89.7% | |
Depression-anxiety | 9.65 (± 5.94) | 8.11 (±4.55) | 8.14 (±5.14) | 8.57 (±5.12) |
90.7% | 91.7% | 88.6 | 90.8% | |
Sedation | 5.13 (± 3.28) | 4.81 (±2.65) | 4.97 (±2.83) | 4.93 (±2.87) |
88.9% | 96.9% | 91.2% | 93.5% | |
Orthostatic hypotension | 3.41 (±2.67) | 2.79 (±2.51) | 2.82 (±2.86) | 2.98 (±2.63) |
81.5% | 75.0% | 70.6% | 76.1% | |
Dermal side effects | 1.11 (±1.46) | 1.09 (±1.62) | 0.97 (±1.43) | 1.08 (±1.53) |
47.3% | 40.6% | 38.2 | 42.2% | |
Sexual side effects | 1.96 (±2.23) | 1.61 (±1.99) | 1.73 (±1.94) | 1.74 (±2.05) |
61.8% | 54.2% | 59.5% | 57.4% | |
Urinary side effects | 2.09 (±1.94) | 1.45 (±1.90) | 1.80 (±2.25) | 1.70 (±1.99) |
74.5% | 49.0% | 54.1% | 57.4% | |