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Table 1 LUNSERS scores (mean ± SD) and frequency of side effects according to genotype and in the total population

From: CYP1A2polymorphism −1545C > T (rs2470890) is associated with increased side effects to clozapine

Symptom LUNSERS scores mean (±SD)
Frequency of the symptom %
  TT (n=54) TC (n=96) CC (n=35) Total (n=185)
Sympathicotonia-tension 7.35 (±4.87) 6.54 (±4.77) 6.69 (±5.61) 6.81 (±4.95)
  88.9% 92.7% 82.9% 89.7%
Depression-anxiety 9.65 (± 5.94) 8.11 (±4.55) 8.14 (±5.14) 8.57 (±5.12)
  90.7% 91.7% 88.6 90.8%
Sedation 5.13 (± 3.28) 4.81 (±2.65) 4.97 (±2.83) 4.93 (±2.87)
  88.9% 96.9% 91.2% 93.5%
Orthostatic hypotension 3.41 (±2.67) 2.79 (±2.51) 2.82 (±2.86) 2.98 (±2.63)
  81.5% 75.0% 70.6% 76.1%
Dermal side effects 1.11 (±1.46) 1.09 (±1.62) 0.97 (±1.43) 1.08 (±1.53)
  47.3% 40.6% 38.2 42.2%
Sexual side effects 1.96 (±2.23) 1.61 (±1.99) 1.73 (±1.94) 1.74 (±2.05)
  61.8% 54.2% 59.5% 57.4%
Urinary side effects 2.09 (±1.94) 1.45 (±1.90) 1.80 (±2.25) 1.70 (±1.99)
  74.5% 49.0% 54.1% 57.4%