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Table 2 Comparisons between CYP1A2 1545C > T (rs2470890) TT and C-carrier patient groups

From: CYP1A2polymorphism −1545C > T (rs2470890) is associated with increased side effects to clozapine

Patients

TT (n=54)

TC/CC (n=133)

PP between groups

Males

32 (59.3%)

78 (58.6%)

NS

Regular smokers

29 (52.7%)

65 (49.6%)

NS

Antipsychotic co-medication

18 (33.3%)

48 (36.1%)

NS

 Atypical

14 (25.9%)

31 (23.3%)

 

 Conventional

2 (3.7%)

16 (12.0%)

 

 Both

2 (3.7%)

1 (0.8%)

 

Mood stabilizer adjuvant therapy

24 (44.4%)

31 (23.3%)

0.004

SSRI/SNRI adjuvant therapy

21 (38.9%)

46 (34.6%)

NS

Clozapine + norclozapine serum level mol/l (mean+SD)

2.21+0.98

2.45+1.36

0.20

Clozapine/norclozapine ratio (mean+SD)

1.68+0.60

1.71+0.59

0.78

Clozapine dose/serum level ratio (mean+SD)

441+195

405+309

0.44

Clozapine dose mg (mean+SD)

431+132

390+150

0.078

Antipsychotic total dose mg* (mean+SD)

971+380

883+389

0.17

  1. *In chlorpromazine equivalents.