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Table 2 Comparisons between CYP1A2 1545C > T (rs2470890) TT and C-carrier patient groups

From: CYP1A2polymorphism −1545C > T (rs2470890) is associated with increased side effects to clozapine

Patients TT (n=54) TC/CC (n=133) PP between groups
Males 32 (59.3%) 78 (58.6%) NS
Regular smokers 29 (52.7%) 65 (49.6%) NS
Antipsychotic co-medication 18 (33.3%) 48 (36.1%) NS
 Atypical 14 (25.9%) 31 (23.3%)  
 Conventional 2 (3.7%) 16 (12.0%)  
 Both 2 (3.7%) 1 (0.8%)  
Mood stabilizer adjuvant therapy 24 (44.4%) 31 (23.3%) 0.004
SSRI/SNRI adjuvant therapy 21 (38.9%) 46 (34.6%) NS
Clozapine + norclozapine serum level mol/l (mean+SD) 2.21+0.98 2.45+1.36 0.20
Clozapine/norclozapine ratio (mean+SD) 1.68+0.60 1.71+0.59 0.78
Clozapine dose/serum level ratio (mean+SD) 441+195 405+309 0.44
Clozapine dose mg (mean+SD) 431+132 390+150 0.078
Antipsychotic total dose mg* (mean+SD) 971+380 883+389 0.17
  1. *In chlorpromazine equivalents.