Table 3 Mean change in PETiT assessments by preswitch medication among patients switched to lurasidone (N = 235)*
| Â | Parameter | Quetiapine | Olanzapine | Risperidone | Aripiprazole | Ziprasidone |
|---|---|---|---|---|---|---|
(n = 62) | (n = 24) | (n = 51) | (n = 44) | (n = 27) | ||
PETiT total score | Baseline (SD) | 31.6 (7.8) | 39.1 (9.9) | 38.3 (8.7) | 35.1 (6.9) | 34.0 (8.5) |
LOCF (SD) | 36.1 (8.5) | 37.5 (13.8) | 41.6 (8.2) | 38.7 (9.1) | 39.3 (7.6) | |
Mean change (SD) | 4.2 (7.7) | -1.3 (11.8) | 3.6 (7.9) | 3.4 (8.0) | 5.4 (7.9) | |
p-value | 0.011 | 0.893 | 0.029 | 0.010 | 0.009 | |
Adherence-related attitude domain score (6 items) | Baseline (SD) | 8.0 (1.9) | 9.1 (2.1) | 9.2 (2.1) | 8.4 (2.0) | 8.6 (2.0) |
LOCF (SD) | 8.8 (2.3) | 9.1 (3.0) | 9.9 (2.1) | 9.5 (2.2) | 9.8 (1.9) | |
Mean change (SD) | 0.8 (2.4) | -0.4 (3.4) | 0.8 (2.0) | 1.0 (2.9) | 1.2 (2.0) | |
p-value | 0.150 | 0.871 | 0.060 | 0.026 | 0.046 | |
Psychosocial functioning domain score (24 items) | Baseline (SD) | 23.6 (6.9) | 30.1 (8.8) | 29.2 (7.6) | 26.8 (6.4) | 25.4 (7.3) |
LOCF (SD) | 27.3 (7.5) | 28.4 (11.2) | 31.7 (7.3) | 29.2 (7.7) | 29.5 (6.7) | |
Mean change (SD) | 3.4 (6.3) | -1.1 (9.1) | 2.8 (7.0) | 2.3 (6.1) | 4.2 (6.6) | |
p-value | 0.015 | 0.898 | 0.048 | 0.020 | 0.006 |