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Table 2 Treatment response - intention to treat analyses

From: The effectiveness of integrated treatment in patients with substance use disorders co-occurring with anxiety and/or depression - a group randomized trial

Response variables

Parameter

Unadjusted

Adjusted

  

Estimate

Sig.

95% CI

Estimate

Sig.

95% CI

    

Lower bound

Upper bound

  

Lower bound

Upper bound

AUDIT

6 months

−1.95

0.197

−4.94

1.03

−1.96

0.195

−4.94

1.02

12 months

−3.11

0.034

−5.97

−0.25

−3.10

0.034

−5.96

−0.23

IG*6 m

−2.72

0.115

−6.10

0.67

−2.63

0.139

−6.12

0.86

IG*12 m

−2.26

0.181

−5.59

1.06

−2.18

0.209

−5.61

1.23

DUDIT

6 months

−1.36

0.459

−4.99

2.27

−1.30

0.478

−4.92

2.32

12 months

−4.50

0.011

−7.97

−1.03

−4.50

0.011

−7.97

−1.04

IG*6 m

−0.39

0.942

−13.61

12.83

−1.49

0.819

−17.30

14.32

IG*12 m

0.74

0.891

−12.48

13.96

−0.29

0.964

−16.11

15.52

SCL-90-anxiety

6 months

−0.16

0.319

−0.48

0.16

−0.16

0.327

−0.48

0.16

12 months

−0.21

0.191

−0.52

0.11

−0.21

0.194

−0.52

0.11

IG*6 m

0.21

0.491

−0.51

0.92

0.20

0.548

−0.58

0.97

IG*12 m

0.12

0.698

−0.60

0.83

0.11

0.744

−0.67

0.88

SCL-90-depres-sion

6 months

−0.20

0.347

−0.61

0.22

−0.19

0.374

−0.60

0.23

12 months

−0.37

0.074

0.77

0.04

−0.36

0.081

−0.76

0.05

IG*6 m

0.18

0.576

−0.54

0.90

0.32

0.437

−0.60

1.24

IG*12 m

0.11

0.744

−0.61

0.82

0.25

0.546

−0.67

1.16

SCL-90-GSI

6 months

−0.19

0.185

−0.47

0.09

−0.18

0.194

−0.46

0.10

12 months

−0.16

0.259

−0.43

0.12

−0.15

0.266

−0.43

0.12

IG*6 m

0.26

0.350

−0.35

0.88

0.27

0.400

−0.45

0.99

IG*12 m

0.03

0.911

−0.58

0.64

0.05

0.884

−0.67

0.76

ASI-alcohol

6 months

−5.97

0.002

−9.63

−2.31

−5.88

0.002

−9.55

−2.21

12 months

−4.10

0.022

−7.62

−0.59

−3.95

0.029

−7.48

−0.42

IG*6 m

−0.55

0.787

−4.53

3.44

2.47

0.210

−1.41

6.36

IG*12 m

−2.73

0.170

−6.65

1.18

0.12

0.951

−3.67

3.90

ASI-Illegal substan-ces

6 months

−5.59

0.141

−13.07

1.88

−5.56

0.143

−13.03

1.90

12 months

−6.39

0.091

−13.82

1.04

−6.45

0.088

−13.87

0.97

IG*6 m

10.02

0.368

−15.36

35.39

9.98

0.364

−15.10

35.06

IG*12 m

8.77

0.426

−16.60

34.13

8.86

0.416

−16.22

33.93

SATS-R

6 months

1.42

0.001

0.57

2.27

1.41

0.001

0.56

2.26

12 months

2.10

<0.001

1.27

2.93

2.09

<0.001

1.25

2.92

IG*6 m

1.59

0.070

−0.16

3.35

1.44

0.085

−0.25

3.12

IG*12 m

1.89

0.038

0.14

3.65

1.76

0.043

0.08

3.44

  1. Examining differences between the Intervention Group and the Control Group in regard to treatment response - Intention to treat analyses.
  2. 6 months = The change of the Control group between baseline and 6 months.
  3. 12 months = The change of the Control group between baseline and 12 months.
  4. IG*6 m = The additional change of the Intervention group between baseline and 6 months compared to the Control Group.
  5. IG*12 m = The additional change of the Intervention group between baseline and 12 months compared to the Control Group.
  6. AUDIT = The Alcohol Use Disorder Identification Test, DUDIT = The Drug Use Disorder Identification Test, SCL-90-Anxiety = The Symptom Check List 90 anxiety sum score, SCL-90-Depression = The Symptom Check List 90 depression sum score, SCL-90-GSI = The Symptom Check List 90 Global Severity Index sum score, ASI-Alcohol = The European Addiction Severity Index, number of days using alcohol on a regular basis during the last 30 days, ASI-Illegal substances = The European Addiction Severity Index, number of days using any illegal substances during the last 30 days, SATS-R = The Substance Abuse Treatment Scale, revised.
  7. Statistical significant values are written in bold types, a 5% alfa-level is used.
  8. A linear multilevel model is used. The different response variables are modelled as a function of group and time. The clustering in the data is accounted for by a random intercept at patient level and at centre level. The primary target of analysis was the interaction between group and time. The analyses where adjusted for by the following covariates: Age, Gender, Living alone, Having his/her own apartment and Having compulsory school only. During the adjusted analyses a non-restricted Log likelihood was used. In the final models, the restricted Log Likelihood was used.
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BMC Psychiatry

ISSN: 1471-244X

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