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Table 2 Adult non-mood Axis I disorders in a 15-year follow-up of adolescents with hypomania spectrum disorder or major depressive disorder (MDD) and of non-mood controls

From: Hypomania spectrum disorder in adolescence: a 15-year follow-up of non-mood morbidity in adulthood

Non-mood Axis I disorders in adulthood (MINI)

Full-syndromal hypomaniaan = 27 (%)

All hypomania spectrum n = 64 (%)

MDD n = 130 (%)

Controls n = 148 (%)

Followed cases

Multiple imputation data

OR (95% CI)dall hypomania vs. MDD

OR (95% CI)dall hypomania vs. controls

OR (95% CI)dall hypomania vs. MDD

OR (95% CI)dall hypomania vs. controls

GADb

6 (22)

12 (19)

19 (15)

7 (5)

1.51 (0.67-3.39)

5.15 (1.90-13.97)***

1.36 (0.64-2.90)

5.72 (2.25-14.58)***

Panic disorderc

6 (22)

14 (22)

23 (18)

11 (7)

1.55 (0.72-3.33)

3.82 (1.61-9.08)**

1.77 (0.87-3.57)

5.01 (2.22-11.29)***

Social anxietyc

5 (19)

11 (17)

27 (21)

10 (7)

0.75 (0.34-1.64)

2.79 (1.11-6.99)*

0.61 (0.29-1.27)

3.36 (1.37-8.27)**

Agoraphobiac

6 (22)

14 (22)

28 (22)

12 (8)

1.14 (0.55-2.39)

3.48 (1.49-8.15)**

1.03 (0.54-1.98)

4.23 (1.94-9.21)***

OCDb

-

4 (6)

6 (5)

2 (1)

1.67 (0.45-6.21)

5.62 (0.99-31.81)

1.42 (0.38-5.32)

4.83 (0.87-27.80)

PTSDb

-

4 (6)

1 (1)

-

8.97 (0.97-83.25)

- 1

9.20 (1.06-79.93)*

- 1

Somatization disorderb

-

1 (2)

3 (2)

-

0.59 (0.07-5.47)

- 1

0.64 (0.07-5.83)

- 1

Dysmorphophobiab

1 (4)

3 (5)

5 (4)

1 (1)

1.48 (0.34-6.46)

8.30 (0.84-81.98)

1.12 (0.26-4.95)

8.66 (0.89-84.49)

Bulimia nervosab

1 (4)

3 (5)

2 (2)

-

3.80 (0.61-23.55)

- 1

8.66 (1.66-48.09)*

- 1

Psychotic symptomsb

-

-

2 (2)

2 (1)

- 1

- 1

- 1

- 1

ADHDb

-

2 (3)

1 (1)

1 (1)

3.85 (0.33-44.89)

4.55 (0.40-51.84)

2.93 (0.24-36.02)

4.82 (0.44-52.41)

Alcohol abusec

4 (15)

10 (16)

17 (13)

11 (7)

1.29 (0.55-3.05)

2.19 (0.87-5.49)

1.39 (0.67-2.87)

3.52 (1.53-8.10)**

Drug abusec

-

4 (6)

8 (6)

3 (2)

2.00 (0.27-15.00)

5.41 (0.48-61.15)

3.75 (0.72-19.53)

14.79 (1.70-128.94)*

Any non- mood morbidity

15 (56)

34 (53)

74 (57)

41 (28)

0.86 (0.46-1.58)

2.98 (1.62-5.50)***

0.85 (0.48-1.51)

4.04 (2.29-7.16)***

  1. * <0.05; ** <0.01; *** < 0.001.
  2. aFull-syndromal hypomania in the follow up is included in all hypomania spectrum, but is also presented separately for transparency.
  3. bCurrent at follow-up.
  4. cAny time from age 19 to follow-up.
  5. dAll p-values adjusted for sex in a logistic regression model.
  6. 1Missing cases in the comparison group; could therefore not be analyzed.
  7. MINI: MINI International Neuropsychiatric Interview Plus; MDD: Major depressive disorder; GAD: Generalized anxiety disorder; OCD: Obsessive-compulsive disorder; PTSD: Posttraumatic stress disorder; ADHD: Attention-deficit/hyperactivity disorder; OR: Odds ratio; CI: Confidence interval.