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Table 4 Adult in- or outpatient care (ICD-10 codes) and prescription drugs (ATC groups) in a 15-year follow-up of adolescents with hypomania spectrum disorder or major depressive disorder (MDD) and of non-mood controls

From: Hypomania spectrum disorder in adolescence: a 15-year follow-up of non-mood morbidity in adulthood

Health service use and prescription drugsa Full-syndromal hypomaniabn = 25 (%) All hypo-mania spectrum n = 58 (%) MDD n = 127 (%) Controls n = 147 (%) Followed cases Multiple imputation data
OR (95% CI)call hypomania vs. MDD OR (95% CI)call hypomania vs. controls OR (95% CI)call hypomania vs. MDD OR (95% CI)call hypomania vs. controls
In- or outpatient care due to mental disorders         
F10-19 Substance related dis. 1 (4) 2 (3) 3 (2) 1 (1) 1.18 (0.18-7.69) 4.35 (0.38-50.31) 1.12 (0.18-6.85) 4.86 (0.43-55.16)
F20-29 Schizophrenia and other psychotic dis. - 1 (2) 1 (1) - 1.64 (0.09-29.21) - 1 1.36 (0.08-22.43) - 1
F30-39 Mood dis. 1 (4) 6 (10) 11 (9) 8 (5) 1.41 (0.49-4.07) 2.31 (0.75-7.11) 1.64 (0.67-4.02) 3.97 (1.42-11.09)**
F40-48 Anxiety and somatoform dis. 1 (4) 9 (16) 14 (11) 5 (3) 1.89 (0.75-4.77) 6.22 (1.95-19.83)** 2.10 (0.91-4.84) 8.20 (2.82-23.87)***
F50-59 Eating dis., sleep dis., sexual dysfunct. - 2 (3) 3 (2) 2 (1) 1.45 (0.23-9.27) 2.93 (0.40-21.45) 2.70 (0.58-12.67) 6.24 (1.02-38.02)*
F60-69 Personality dis. - - 4 (3) 2 (1) - 1 - 1 - 1 - 1
In- or outpatient care due to physical diseases         
K00-K93 Diseases of the digestive system 7 (28) 15 (26) 23 (18) 18 (12) 1.64 (0.77-3.48) 2.44 (1.13-5.28)* 1.75 (0.87-3.52) 3.38 (1.69-6.79)***
S00-S98 Injury, poisoning and certain other consequences of external causes 6 (24) 22 (38) 41 (32) 31 (21) 1.17 (0.60-2.27) 2.14 (1.08-4.26)* 1.65 (0.93-2.90) 3.78 (2.09-6.86)***
Prescription drugs         
L. Antineoplastic and immunomodulating agents 1 (4) 4 (7) 1 (1) 1 (1) 9.72 (1.04-90.78)* 10.17 (1.10-93.78)* 9.25 (0.98-87.32) 11.17 (1.13-110.00)*
N. Nervous system 9 (36) 29 (50) 74 (58) 59 (40) 1.01 (0.79-1.30) 1.59 (1.19-2.13)** 1.11 (0.62-1.97) 3.23 (1.87-5.57)***
N03 Anticonvulsants - - 6 (5) 1 (1) - 1 - 1 - 1 - 1
N05a Antipsychotics 1 (4) 4 (7) 2 (2) - 4.90 (0.85-28.14) - 1 7.82 (1.53-39.92)* - 1
N05b Anxiolytics 4 (16) 11 (19) 15 (12) 6 (4) 2.02 (0.85-4.82) 5.74 (2.00-16.50)*** 1.80 (0.83-3.87) 7.14 (2.88-17.73)***
N05c Hypnotics and sedatives - 9 (16) 21 (17) 13 (9) 0.82 (0.34-1.96) 1.89 (0.76-4.72) 0.91 (0.42-1.94) 2.57 (1.11-5.93)*
N06a Antidepressants 6 (24) 18 (31) 35 (28) 19 (13) 1.31 (0.65-2.62) 3.06 (1.46-6.42)** 1.33 (0.72-2.46) 4.74 (2.43-9.22)***
N06b Psychostimulants - - 3 (2) - - 1 - 1 - 1 - 1
N07 Drugs for addictive disorders - 2 (3) 6 (5) - 0.88 (0.17-4.52) - 1 0.70 (0.14-3.35) - 1
  1. * <0.05; ** <0.01; *** < 0.001.
  2. aOnly diagnostic groups with significant group differences or of specific interest are shown.
  3. bFull-syndromal hypomania in the follow up is included in all hypomania spectrum, but is also presented separately for transparency.
  4. cAll p-values adjusted for sex in a logistic regression model.
  5. 1Missing cases in the comparison group; could therefore not be analyzed.
  6. ICD-10: International Statistical Classification of Diseases and Related Health Problems, Tenth Revision; ATC groups: Anatomic Therapeutic Chemical classification system; MDD: Major depressive disorder; OR: Odds ratio; CI: Confidence interval.