Figure 1

Regions where the schizophrenia group showed significantly lower fractional anisotropy (FA) compared to healthy controls. Upper two rows: The regions of reduction detected by Tract-based spatial statistics (TBSS) are shown in red (false discovery rate p < 0.05) superimposed on illustrative axial slices (Talairach level shown above each slice; left brain on left side of image). Reductions are particularly concentrated in medial frontal sectors. Lower two rows: For comparison with the white matter atlas parcellation findings, the white matter regions corresponding to the following are shown in colour (superimposed on the TBSS reductions in red): genu of corpus callosum (atlas region 3; pink), left anterior corona radiata (atlas region 23, yellow), left anterior limb of the internal capsule (atlas region 17, blue) and left superior fronto-occipital fasciculus/anterior limb of the internal capsule (atlas region 43, green).