Agent | Level of evidence | Agent | Level of evidence |
---|---|---|---|
Antidepressants | |||
SSRIs | Â | TCAs | Â |
1 | 1 | ||
1 | 1 | ||
1 | MAOIs and RIMAs | Â | |
1 | Phenelzine [240] | 2 | |
1 | 1* | ||
Escitalopram [198] | 2 | Tranylcypromine [243] | 3 |
Paroxetine CR [225] | 2 | Other antidepressants | Â |
SNRIs | Â | 1 | |
1 | 2 | ||
Duloxetine [230] | 3 | 3* | |
Milnacipran [231] | 3 | Â | Â |
Other therapies | |||
Anxiolytics | Â | Atypical antipsychotics | Â |
    Benzodiazepines |  | 2 | |
1 | Olanzapine [268] | 3 | |
1 | Quetiapine [267] | 3 | |
1 | Adjunctive aripiprazole [269] | 3 | |
1 | Adjunctive olanzapine [270] | 3 | |
1 | Adjunctive risperidone [271] | 3 | |
      Adjunctive alprazolam ODT [266] | 3 | Anticonvulsants |  |
Other treatments | Â | 3 | |
1 (-ve) | Levetiracetam [276] | 3 | |
Trazodone [283] | 2 (-ve) | Gabapentin [277] | 2 (-ve)†|
2 (-ve) | 2 (-ve) | ||
Adjunctive pindolol [286] | 2 | Carbamazepine [280] | 3 (-ve) |
 |  | Adjunctive divalproex [281] | 3 |