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Table 15 Recommendations for pharmacotherapy for panic disorder

From: Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders

First-line Citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, paroxetine CR, sertraline, venlafaxine XR
Second-line Alprazolam, clomipramine, clonazepam, diazepam, imipramine, lorazepam, mirtazapine, reboxetine
Third-line Bupropion SR, divalproex, duloxetine, gabapentin, levetiracetam, milnacipran, moclobemide, olanzapine, phenelzine, quetiapine, risperidone, tranylcypromine
Adjunctive therapy Second-line: alprazolam ODT, clonazepam
Third-line: aripiprazole, divalproex, olanzapine, pindolol, risperidone
Not recommended Buspirone, propranolol, tiagabine, trazodone
  1. CR = controlled release; ODT = orally disintegrating tablets; SR = sustained release; XR = extended release.