Table 30 Recommendations for pharmacotherapy for core symptoms of PTSD
| First-line | Fluoxetine, paroxetine, sertraline, venlafaxine XR |
| Second-line | Fluvoxamine, mirtazapine, phenelzine |
| Third-line | Amitriptyline, aripiprazole, bupropion SR, buspirone, carbamazepine, desipramine, duloxetine, escitalopram, imipramine, lamotrigine, memantine, moclobemide, quetiapine, reboxetine, risperidone, tianeptine, topiramate, trazodone |
| Adjunctive therapy |
Second-line: eszopiclone, olanzapine, risperidone Third-line: aripiprazole, clonidine, gabapentin, levetiracetam, pregabalin, quetiapine, reboxetine, tiagabine Not recommended: bupropion SR, guanfacine, topiramate, zolpidem |
| Not recommended | Alprazolam, citalopram, clonazepam, desipramine, divalproex, olanzapine, tiagabine |