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Table 9 Sample size needed to detect an absolute difference of 15% in the proportion of tranquillised patients (α = 5%, power = 80%).

From: TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243]

Haloperidol + promethazine (% tranquilised) Midazolam (% tranquilised) N
5 20 152
10 25 200
15 30 242
20 35 276
25 40 304
30 45 326
35 50 340