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Table 3 Clinical outcome of the ITT sample by depression groups

From: Differential response to right unilateral ECT in depressed patients: impact of comorbidity and severity of illness [ISRCTN39974945]

 

Whole Group

Group 1

Group 2

P

 

Mean ± SD

Mean ± SD

Mean ± SD

 

HDRS change (%)

45.6 ± 26.0

64.3 ± 18.7

33.1 ± 22.7

<0.0001d

Responders (yes/no)a

12/28

10/6

2/22

0.0004

No. of treatments

7.7 ± 3.2

8.3 ± 2.5

7.4 ± 3.5

ns

MMSE change (%)b

-1.8 ± -10.1

2.7 ± 11.2

-5.3 ± -7.6

0.0159e

Cognitive risk (yes/no)c

18/18

6/10

12/8

ns

Cognitive risk and nonresponse (yes/no)

11/25

1/15

10/10

0.0091

  1. Fisher's Exact Test is used for nominal variables and independent sample t-test or Mann-Whitney U test (for non-normal distributions) for continuous variables. aResponse = HDRS change (%)≥ 60, and post-ECT HDRS score < 10. bPositive values on percentage change indicate a better cognitive functioning as compared with baseline. cCognitive risk = MMSE change < 0%. d P = 0.0036 using ANCOVA with pre-ECT HDRS score and age as covariates. e P = 0.1803 using ANCOVA with pre-ECT MMSE score and age as covariates.