|  | STUDY 1 | STUDY 2 | ||||||
---|---|---|---|---|---|---|---|---|---|
MMRM | |||||||||
THERAPY | Week | N | Mean change | Std.error | p-value | N | Mean change | Std.error | p-value |
DULOX | 1 | 121 | -2.89 | 0.36 | .435 | 123 | -2.89 | 0.38 | .601 |
PLACEBO | 1 | 115 | -2.50 | 0.37 | Â | 136 | -2.64 | 0.36 | Â |
DULOX | 2 | 112 | -5.72 | 0.49 | < .001 | 109 | -5.54 | 0.48 | .071 |
PLACEBO | 2 | 110 | -3.39 | 0.50 | Â | 129 | -4.43 | 0.45 | Â |
DULOX | 3 | 105 | -7.37 | 0.53 | < .001 | 108 | -6.82 | 0.55 | .287 |
PLACEBO | 3 | 103 | -4.58 | 0.54 | Â | 122 | -6.06 | 0.52 | Â |
DULOX | 5 | 100 | -8.76 | 0.60 | < .001 | 98 | -8.58 | 0.66 | .116 |
PLACEBO | 5 | 101 | -5.74 | 0.60 | Â | 111 | -7.20 | 0.62 | Â |
DULOX | 7 | 91 | -9.93 | 0.64 | < .001 | 89 | -10.14 | 0.69 | .008 |
PLACEBO | 7 | 93 | -5.82 | 0.65 | Â | 97 | -7.69 | 0.65 | Â |
DULOX | 9 | 84 | -10.91 | 0.70 | < .001 | 81 | -10.46 | 0.71 | .024 |
PLACEBO | 9 | 89 | -6.05 | 0.69 | Â | 90 | -8.29 | 0.67 | Â |
LOCF_ANCOVA | |||||||||
DULOX | LOCF_ANCOVA | 121 | -9.47 | 0.63 | < .001 | 123 | -8.75 | 0.71 | .048 |
PLACEBO | LOCF_ANCOVA | 115 | -5.67 | 0.66 | Â | 136 | -7.02 | 0.68 | Â |