| | | |
5-HIAA
|
HVA
|
MHPG
|
|---|
|
HTR2C Allele/genotype
|
Sex
|
n
|
Mean ± SD (nmol/L)
|
Fa pa
|
Fb pb
|
Mean ± SD (nmol/L)
|
Fa pa
|
Fb pb
|
Mean ± SD (nmol/L)
|
Fa pa
|
Fb pb
|
|---|
|
Cys23
|
Men
|
43
|
92 ± 40
|
F = 0.27
|
F = 0.13
|
166 ± 75
|
F = 0.73
|
F = 0.50
|
43 ± 8
|
F = 1.75
|
F = 1.48
|
|
Ser23
| |
6
|
86 ± 16
|
p = 0.61
|
p = 0.72
|
144 ± 39
|
p = 0.40
|
p = 0.48
|
39 ± 4
|
p = 0.19
|
p = 0.23
|
|
Cys23Cys
|
Women
|
30
|
105 ± 39
|
F = 0.66
|
F = 0.57
|
194 ± 77
|
F = 2.14
|
F = 1.34
|
40 ± 6
|
F = 1.03
|
F = 0.91
|
|
Cys23Serc
| |
6
|
118 ± 29
|
p = 0.42
|
p = 0.46d
|
231 ± 69
|
p = 0.15
|
p = 0.25e
|
44 ± 8
|
p = 0.32
|
p = 0.35f
|
|
Ser23Serc
| |
1
|
107
| | |
229
| | |
38
| | |
- 5-HIAA = 5-hydroxyindoleacetic acid; HVA = homovanillic acid; MHPG = 3-methoxy-4-hydroxyphenylglycol. Statistical comparisons done on monoamine metabolite residuals correcteda and uncorrectedb for back length. c Cys23Ser and Ser23Ser genotypes were combined in the analyses. d Correction for use of oral contraceptives, F = 0.21, p = 0.65. e Correction for use of oral contraceptives, F = 0.84, p = 0.37. f Correction for use of oral contraceptives, F = 0.22, p = 0.64.
