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Table 1 Serotonin receptor 5-HT2C (HTR2C) genotypes and relationships to monoamine metabolite concentrations in human lumbar cerebrospinal fluid.

From: Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers

    5-HIAA HVA MHPG
HTR2C Allele/genotype Sex n Mean ± SD (nmol/L) Fa pa Fb pb Mean ± SD (nmol/L) Fa pa Fb pb Mean ± SD (nmol/L) Fa pa Fb pb
Cys23 Men 43 92 ± 40 F = 0.27 F = 0.13 166 ± 75 F = 0.73 F = 0.50 43 ± 8 F = 1.75 F = 1.48
Ser23   6 86 ± 16 p = 0.61 p = 0.72 144 ± 39 p = 0.40 p = 0.48 39 ± 4 p = 0.19 p = 0.23
Cys23Cys Women 30 105 ± 39 F = 0.66 F = 0.57 194 ± 77 F = 2.14 F = 1.34 40 ± 6 F = 1.03 F = 0.91
Cys23Serc   6 118 ± 29 p = 0.42 p = 0.46d 231 ± 69 p = 0.15 p = 0.25e 44 ± 8 p = 0.32 p = 0.35f
Ser23Serc   1 107    229    38   
  1. 5-HIAA = 5-hydroxyindoleacetic acid; HVA = homovanillic acid; MHPG = 3-methoxy-4-hydroxyphenylglycol. Statistical comparisons done on monoamine metabolite residuals correcteda and uncorrectedb for back length. c Cys23Ser and Ser23Ser genotypes were combined in the analyses. d Correction for use of oral contraceptives, F = 0.21, p = 0.65. e Correction for use of oral contraceptives, F = 0.84, p = 0.37. f Correction for use of oral contraceptives, F = 0.22, p = 0.64.