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Table 2 Serotonin receptor 5-HT3A (HTR3A) genotypes and relationships to monoamine metabolite concentrations in human lumbar cerebrospinal fluid.

From: Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers

    5-HIAA HVA MHPG
HTR3A Genotype Sex n Mean ± SD (nmol/L) Fa pa Fb pb Mean ± SD (nmol/L) Fa pa Fb pb Mean ± SD (nmol/L) Fa pa Fb pb
T/Tc All 3 105 ± 52 F = 5.75 F = 10.22 203 ± 124 F = 3.25 F = 7.95 44 ± 5 F = 0.45 F = 0.29
C/Tc   27 117 ± 36 p = 0.02 p = 0.002 211 ± 67 p = 0.07 p = 0.006 43 ± 8 p = 0.50 p = 0.75
C/C   60 90 ± 35    166 ± 71    42 ± 7   
T/Tc Men 1 52 F = 0.31 F = 0.96 113 F = 0.75 F = 1.49 49 F = 0.20 F = 0.49
C/Tc   11 106 ± 33 p = 0.58 p = 0.33 193 ± 50 p = 0.39 p = 0.23 44 ± 9 p = 0.66 p = 0.49
C/C   40 90 ± 37    159 ± 11    43 ± 7   
T/Tc Women 2 131 ± 34 F = 8.55 F = 9.75 248 ± 137 F = 2.49 F = 4.05 41 ± 3 F = 0.68 F = 1.00
C/Tc   16 124 ± 37 p = 0.006 p = 0.004d 224 ± 76 p = 0.12 p = 0.05e 42 ± 7 p = 0.42 p = 0.32f
C/C   20 92 ± 30    179 ± 64    40 ± 6   
  1. 5-HIAA = 5-hydroxyindoleacetic acid; HVA = homovanillic acid; MHPG = 3-methoxy-4-hydroxyphenylglycol. Statistical comparisons done on monoamine metabolite residuals correcteda and uncorrectedb for back length. c T/T and C/T genotypes were combined in the analyses. d Correction for use of oral contraceptives, F = 5.56, p = 0.02. e Correction for use of oral contraceptives, F = 1.76, p = 0.19. f Correction for use of oral contraceptives, F = 0.17, p = 0.68. Analysing heterosis, i.e. comparing homo- vs heterozygotes: All subjects 5-HIAA: F = 10.03, p = 0.002 (F = 5.71, p = 0.02 after correction for back length). All subjects HVA: F = 7.13, p = 0.009 (F = 2.28, p = 0.10). Men 5-HIAA: F = 1.96, p = 0.17 (F = 1.00, p = 0.32). Men HVA: 2.33, p = 0.13 (F = 1.40, p = 0.24). Women 5-HIAA: F = 6.73, p = 0.01 (F = 5.65, p = 0.02 and F = 3.76, p = 0.06 corrected for back length and use of oral contraceptives, respectively). Women HVA: F = 2.49, p = 0.12 (F = 1.03, p = 0.32 and F = 0.98, p = 0.33 corrected for back length and use of oral contraceptives, respectively).