Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers

Table 2 Serotonin receptor 5-HT_3A (HTR3A) genotypes and relationships to monoamine metabolite concentrations in human lumbar cerebrospinal fluid.

5-HIAA = 5-hydroxyindoleacetic acid; HVA = homovanillic acid; MHPG = 3-methoxy-4-hydroxyphenylglycol. Statistical comparisons done on monoamine metabolite residuals corrected^a and uncorrected^b for back length. ^c T/T and C/T genotypes were combined in the analyses. ^d Correction for use of oral contraceptives, F = 5.56, p = 0.02. ^e Correction for use of oral contraceptives, F = 1.76, p = 0.19. ^f Correction for use of oral contraceptives, F = 0.17, p = 0.68. Analysing heterosis, i.e. comparing homo- vs heterozygotes: All subjects 5-HIAA: F = 10.03, p = 0.002 (F = 5.71, p = 0.02 after correction for back length). All subjects HVA: F = 7.13, p = 0.009 (F = 2.28, p = 0.10). Men 5-HIAA: F = 1.96, p = 0.17 (F = 1.00, p = 0.32). Men HVA: 2.33, p = 0.13 (F = 1.40, p = 0.24). Women 5-HIAA: F = 6.73, p = 0.01 (F = 5.65, p = 0.02 and F = 3.76, p = 0.06 corrected for back length and use of oral contraceptives, respectively). Women HVA: F = 2.49, p = 0.12 (F = 1.03, p = 0.32 and F = 0.98, p = 0.33 corrected for back length and use of oral contraceptives, respectively).

ISSN: 1471-244X