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Table 3 Dopamine D4 receptor (DRD4) genotypes and relationships to monoamine metabolite concentrations in human lumbar cerebrospinal fluid.

From: Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers

   

5-HIAA

HVA

MHPG

DRD4 Genotype

Sex

n

Mean ± SD (nmol/L)

Fa pa

Fb pb

Mean ± SD (nmol/L)

Fa pa

Fb pb

Mean ± SD (nmol/L)

Fa pa

Fb pb

C/C

All

13

104 ± 43

F = 0.76

F = 0.22

199 ± 94

F = 1.39

F = 0.52

42 ± 7

F = 2.62

F = 2.68

C/T

 

52

99 ± 34

p = 0.47

p = 0.80

176 ± 68

p = 0.25

p = 0.59

41 ± 7

p = 0.08

p = 0.07

T/T

 

25

96 ± 41

  

181 ± 77

  

45 ± 8

  

C/C

Men

12

104 ± 44

F = 0.99

F = 0.98

197 ± 98

F = 1.49

F = 1.60

43 ± 7

F = 1.93

F = 2.06

C/T

 

26

91 ± 35

p = 0.38

p = 0.38

156 ± 63

p = 0.24

p = 0.21

41 ± 8

p = 0.16

p = 0.14

T/T

 

14

84 ± 32

  

155 ± 50

  

46 ± 8

  

C/Cc

Women

1

107

F = 0.004

F = 0.11

229

F = 0.003

F = 0.48

38

F = 0.78

F = 1.23

C/Tc

 

26

106 ± 33

p = 0.95

p = 0.74d

195 ± 68

p = 0.96

p = 0.49e

40 ± 6

p = 0.38

p = 0.27f

T/T

 

11

111 ± 47

  

214 ± 93

  

43 ± 7

  
  1. 5-HIAA = 5-hydroxyindoleacetic acid; HVA = homovanillic acid; MHPG = 3-methoxy-4-hydroxyphenylglycol. Statistical comparisons done on monoamine metabolite residuals correcteda and uncorrectedb for back length. c C/C and C/T genotypes were combined in the analyses. d Correction for use of oral contraceptives, F = 0.38, p = 0.54. e Correction for use of oral contraceptives, F = 0.04, p = 0.84. f Correction for use of oral contraceptives, F = 1.09, p = 0.30.
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BMC Psychiatry

ISSN: 1471-244X

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