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Table 3 Dopamine D4 receptor (DRD4) genotypes and relationships to monoamine metabolite concentrations in human lumbar cerebrospinal fluid.

From: Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers

    5-HIAA HVA MHPG
DRD4 Genotype Sex n Mean ± SD (nmol/L) Fa pa Fb pb Mean ± SD (nmol/L) Fa pa Fb pb Mean ± SD (nmol/L) Fa pa Fb pb
C/C All 13 104 ± 43 F = 0.76 F = 0.22 199 ± 94 F = 1.39 F = 0.52 42 ± 7 F = 2.62 F = 2.68
C/T   52 99 ± 34 p = 0.47 p = 0.80 176 ± 68 p = 0.25 p = 0.59 41 ± 7 p = 0.08 p = 0.07
T/T   25 96 ± 41    181 ± 77    45 ± 8   
C/C Men 12 104 ± 44 F = 0.99 F = 0.98 197 ± 98 F = 1.49 F = 1.60 43 ± 7 F = 1.93 F = 2.06
C/T   26 91 ± 35 p = 0.38 p = 0.38 156 ± 63 p = 0.24 p = 0.21 41 ± 8 p = 0.16 p = 0.14
T/T   14 84 ± 32    155 ± 50    46 ± 8   
C/Cc Women 1 107 F = 0.004 F = 0.11 229 F = 0.003 F = 0.48 38 F = 0.78 F = 1.23
C/Tc   26 106 ± 33 p = 0.95 p = 0.74d 195 ± 68 p = 0.96 p = 0.49e 40 ± 6 p = 0.38 p = 0.27f
T/T   11 111 ± 47    214 ± 93    43 ± 7   
  1. 5-HIAA = 5-hydroxyindoleacetic acid; HVA = homovanillic acid; MHPG = 3-methoxy-4-hydroxyphenylglycol. Statistical comparisons done on monoamine metabolite residuals correcteda and uncorrectedb for back length. c C/C and C/T genotypes were combined in the analyses. d Correction for use of oral contraceptives, F = 0.38, p = 0.54. e Correction for use of oral contraceptives, F = 0.04, p = 0.84. f Correction for use of oral contraceptives, F = 1.09, p = 0.30.