| | | 5-HIAA | HVA | MHPG |
---|
DBH Genotype | Sex | n | Mean ± SD (nmol/L) | Fa pa
| Fb pb
| Mean ± SD (nmol/L) | Fa pa
| Fb pb
| Mean ± SD (nmol/L) | Fa pa
| Fb pb
|
---|
C/C | All | 64 | 92 ± 35 | F = 9.07 | F = 6.42 | 172 ± 66 | F = 5.21 | F = 3.00 | 42 ± 7 | F = 0.01 | F = 0.01 |
C/Tc
| | 23 | 118 ± 39 | p = 0.003 | p = 0.01 | 208 ± 93 | p = 0.02 | p = 0.09 | 42 ± 9 | p = 0.90 | p = 0.93 |
T/Tc
| | 3 | 78 ± 25 | | | 151 ± 18 | | | 40 ± 5 | | |
C/C | Men | 36 | 86 ± 36 | F = 4.68 | F = 3.80 | 156 ± 56 | F = 2.22 | F = 1.81 | 43 ± 7 | F = 0.08 | F = 0.04 |
C/Tc
| | 15 | 107 ± 35 | p = 0.04 | p = 0.06 | 186 ± 98 | p = 0.14 | p = 0.18 | 43 ± 10 | p = 0.78 | p = 0.84 |
T/Tc
| | 1 | 95 | | | 160 | | | 45 | | |
C/C | Women | 28 | 101 ± 31 | F = 4.08 | F = 3.37 | 192 ± 73 | F = 3.72 | F = 1.79 | 41 ± 6 | F = 0.03 | F = 0.08 |
C/Tc
| | 8 | 139 ± 38 | p = 0.05 | p = 0.07e
| 249 ± 72 | p = 0.06 | p = 0.19d
| 41 ± 7 | p = 0.87 | p = 0.78f
|
T/Tc
| | 2 | 70 ± 30 | | | 147 ± 23 | | | 38 ± 4 | | |
- 5-HIAA = 5-hydroxyindoleacetic acid; HVA = homovanillic acid; MHPG = 3-methoxy-4-hydroxyphenylglycol. Statistical comparisons done on monoamine metabolite residuals correcteda and uncorrectedb for back length. c T/T and C/T genotypes were combined in the analyses. d Correction for use of oral contraceptives, F = 0.88, p = 0.36. e Correction for use of oral contraceptives, F = 0.46, p = 0.50. f Correction for use of oral contraceptives, F = 0.003, p = 0.96. Analysing heterosis, i.e. comparing homo- vs heterozygotes: All subjects 5-HIAA: F = 9.56, p = 0.003 (F = 13.07, p = 0.0005 after correction for back length). All subjects HVA: F = 4.43, p = 0.04 (F = 7.24, p = 0.009). Men 5-HIAA: F = 3.85, p = 0.06 (F = 4.6187, p = 0.04). Men HVA: 1.95, p = 0.17 (F = 2.31, p = 0.14). Women 5-HIAA: F = 9.14, p = 0.005 (F = 9.74, p = 0.004 and F = 4.11, p = 0.05 corrected for back length and use of oral contraceptives, respectively). Women HVA: F = 4.43, p = 0.04 (F = 6.42, p = 0.02 and F = 1.81, p = 0.19 corrected for back length and use of oral contraceptives, respectively).