Skip to main content

Table 4 Dopamine β-hydroxylase (DBH) genotypes and relationships to monoamine metabolite concentrations in human lumbar cerebrospinal fluid.

From: Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers

    5-HIAA HVA MHPG
DBH Genotype Sex n Mean ± SD (nmol/L) Fa pa Fb pb Mean ± SD (nmol/L) Fa pa Fb pb Mean ± SD (nmol/L) Fa pa Fb pb
C/C All 64 92 ± 35 F = 9.07 F = 6.42 172 ± 66 F = 5.21 F = 3.00 42 ± 7 F = 0.01 F = 0.01
C/Tc   23 118 ± 39 p = 0.003 p = 0.01 208 ± 93 p = 0.02 p = 0.09 42 ± 9 p = 0.90 p = 0.93
T/Tc   3 78 ± 25    151 ± 18    40 ± 5   
C/C Men 36 86 ± 36 F = 4.68 F = 3.80 156 ± 56 F = 2.22 F = 1.81 43 ± 7 F = 0.08 F = 0.04
C/Tc   15 107 ± 35 p = 0.04 p = 0.06 186 ± 98 p = 0.14 p = 0.18 43 ± 10 p = 0.78 p = 0.84
T/Tc   1 95    160    45   
C/C Women 28 101 ± 31 F = 4.08 F = 3.37 192 ± 73 F = 3.72 F = 1.79 41 ± 6 F = 0.03 F = 0.08
C/Tc   8 139 ± 38 p = 0.05 p = 0.07e 249 ± 72 p = 0.06 p = 0.19d 41 ± 7 p = 0.87 p = 0.78f
T/Tc   2 70 ± 30    147 ± 23    38 ± 4   
  1. 5-HIAA = 5-hydroxyindoleacetic acid; HVA = homovanillic acid; MHPG = 3-methoxy-4-hydroxyphenylglycol. Statistical comparisons done on monoamine metabolite residuals correcteda and uncorrectedb for back length. c T/T and C/T genotypes were combined in the analyses. d Correction for use of oral contraceptives, F = 0.88, p = 0.36. e Correction for use of oral contraceptives, F = 0.46, p = 0.50. f Correction for use of oral contraceptives, F = 0.003, p = 0.96. Analysing heterosis, i.e. comparing homo- vs heterozygotes: All subjects 5-HIAA: F = 9.56, p = 0.003 (F = 13.07, p = 0.0005 after correction for back length). All subjects HVA: F = 4.43, p = 0.04 (F = 7.24, p = 0.009). Men 5-HIAA: F = 3.85, p = 0.06 (F = 4.6187, p = 0.04). Men HVA: 1.95, p = 0.17 (F = 2.31, p = 0.14). Women 5-HIAA: F = 9.14, p = 0.005 (F = 9.74, p = 0.004 and F = 4.11, p = 0.05 corrected for back length and use of oral contraceptives, respectively). Women HVA: F = 4.43, p = 0.04 (F = 6.42, p = 0.02 and F = 1.81, p = 0.19 corrected for back length and use of oral contraceptives, respectively).