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Table 4 Dopamine β-hydroxylase (DBH) genotypes and relationships to monoamine metabolite concentrations in human lumbar cerebrospinal fluid.

From: Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers

   

5-HIAA

HVA

MHPG

DBH Genotype

Sex

n

Mean ± SD (nmol/L)

Fa pa

Fb pb

Mean ± SD (nmol/L)

Fa pa

Fb pb

Mean ± SD (nmol/L)

Fa pa

Fb pb

C/C

All

64

92 ± 35

F = 9.07

F = 6.42

172 ± 66

F = 5.21

F = 3.00

42 ± 7

F = 0.01

F = 0.01

C/Tc

 

23

118 ± 39

p = 0.003

p = 0.01

208 ± 93

p = 0.02

p = 0.09

42 ± 9

p = 0.90

p = 0.93

T/Tc

 

3

78 ± 25

  

151 ± 18

  

40 ± 5

  

C/C

Men

36

86 ± 36

F = 4.68

F = 3.80

156 ± 56

F = 2.22

F = 1.81

43 ± 7

F = 0.08

F = 0.04

C/Tc

 

15

107 ± 35

p = 0.04

p = 0.06

186 ± 98

p = 0.14

p = 0.18

43 ± 10

p = 0.78

p = 0.84

T/Tc

 

1

95

  

160

  

45

  

C/C

Women

28

101 ± 31

F = 4.08

F = 3.37

192 ± 73

F = 3.72

F = 1.79

41 ± 6

F = 0.03

F = 0.08

C/Tc

 

8

139 ± 38

p = 0.05

p = 0.07e

249 ± 72

p = 0.06

p = 0.19d

41 ± 7

p = 0.87

p = 0.78f

T/Tc

 

2

70 ± 30

  

147 ± 23

  

38 ± 4

  
  1. 5-HIAA = 5-hydroxyindoleacetic acid; HVA = homovanillic acid; MHPG = 3-methoxy-4-hydroxyphenylglycol. Statistical comparisons done on monoamine metabolite residuals correcteda and uncorrectedb for back length. c T/T and C/T genotypes were combined in the analyses. d Correction for use of oral contraceptives, F = 0.88, p = 0.36. e Correction for use of oral contraceptives, F = 0.46, p = 0.50. f Correction for use of oral contraceptives, F = 0.003, p = 0.96. Analysing heterosis, i.e. comparing homo- vs heterozygotes: All subjects 5-HIAA: F = 9.56, p = 0.003 (F = 13.07, p = 0.0005 after correction for back length). All subjects HVA: F = 4.43, p = 0.04 (F = 7.24, p = 0.009). Men 5-HIAA: F = 3.85, p = 0.06 (F = 4.6187, p = 0.04). Men HVA: 1.95, p = 0.17 (F = 2.31, p = 0.14). Women 5-HIAA: F = 9.14, p = 0.005 (F = 9.74, p = 0.004 and F = 4.11, p = 0.05 corrected for back length and use of oral contraceptives, respectively). Women HVA: F = 4.43, p = 0.04 (F = 6.42, p = 0.02 and F = 1.81, p = 0.19 corrected for back length and use of oral contraceptives, respectively).