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Table 1 Numbers of randomized patients

From: Duloxetine in the treatment of Major Depressive Disorder: A comparison of efficacy in patients with and without melancholic features

Study Placebo SSRIa Duloxetine
    40 mg/db 60 mg QD 80 mg/dc 120 mg/dd
1 70 (80.0) 33 (72.7) - - - 70 (77.1)
2 74 (73.0) 37 (86.5) - - - 82 (69.5)
3 90 (55.6) 89 (64.0) 91 (62.6) - 84 (60.7) -
4 89 (66.3) 87 (63.2) 86 (72.1) - 91 (69.2) -
5 121 (69.4) - - 122 (63.1) - -
6 139 (62.6) - - 128 (62.5) - -
7 93 (66.7) 86 (68.6) - - 95 (65.3) 93 (66.7)
8 99 (67.7) 97 (69.1) - - 93 (71.0) 103 (66.0)
TOTAL 775 (67.0) 429 (68.5) 1138 (66.7)
  1. Data presented in the form T (% M), where T = total number of patients, % M = percentage of patients with melancholic features
  2. a. SSRI in Studies 1 and 2 is fluoxetine (20 mg QD). SSRI in Studies 3, 4, 7, and 8 is paroxetine (20 mg QD).
  3. b. Administered 20 mg twice-daily (BID)
  4. c. Administered 40 mg BID
  5. d. Administered 60 mg BID. Studies 1 and 2 incorporated a forced titration from 20 mg BID to 60 mg BID.