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Table 4 Mean changes from baseline to last observation by gender in melancholic patients

From: Duloxetine in the treatment of Major Depressive Disorder: A comparison of efficacy in patients with and without melancholic features

 

Gender

Mean Change (SD)

p-valuea

p-valueb

  

Duloxetine

Placebo

  

HAMD 17 Total Score

Male (n = 386)

-7.99 (7.04)

-5.95 (7.13)

.003

.932

 

Female (n = 863)

-9.42 (7.46)

-6.83 (7.29)

<.001

 

CGI-Severity

Male (n = 386)

-1.41 (1.28)

-0.97 (1.22)

.001

.668

 

Female (n = 865)

-1.57 (1.24)

-1.17 (1.20)

<.001

 
 

Mean (SD)

PGI-Improvement

Male (n = 385)

2.80 (1.27)

3.13 (1.23)

.009

.877

 

Female (n = 864)

2.61 (1.26)

3.04 (1.29)

<.001

 
  1. a. p-value for duloxetine vs. placebo
  2. b. p-value for treatment-by-gender interaction
  3. † Mean score (SD). Lower mean score indicates greater improvement.