Skip to main content

Table 4 Mean changes from baseline to last observation by gender in melancholic patients

From: Duloxetine in the treatment of Major Depressive Disorder: A comparison of efficacy in patients with and without melancholic features

  Gender Mean Change (SD) p-valuea p-valueb
   Duloxetine Placebo   
HAMD 17 Total Score Male (n = 386) -7.99 (7.04) -5.95 (7.13) .003 .932
  Female (n = 863) -9.42 (7.46) -6.83 (7.29) <.001  
CGI-Severity Male (n = 386) -1.41 (1.28) -0.97 (1.22) .001 .668
  Female (n = 865) -1.57 (1.24) -1.17 (1.20) <.001  
  Mean (SD)
PGI-Improvement Male (n = 385) 2.80 (1.27) 3.13 (1.23) .009 .877
  Female (n = 864) 2.61 (1.26) 3.04 (1.29) <.001  
  1. a. p-value for duloxetine vs. placebo
  2. b. p-value for treatment-by-gender interaction
  3. † Mean score (SD). Lower mean score indicates greater improvement.