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Table 5 Mean changes from baseline to last observation in active comparator studies

From: Duloxetine in the treatment of Major Depressive Disorder: A comparison of efficacy in patients with and without melancholic features

  Melancholic Status Mean Change (SD) p-valuea p-valueb
   Duloxetine SSRI   
HAMD 17 Total Score MEL (n = 878) -8.85 (7.39) -8.60 (7.68) .709 .784
  NON-MEL (n = 416) -8.18 (6.52) -7.59 (6.70) .897  
CGI-Severity MEL (n = 880) -1.53 (1.26) -1.52 (1.33) .979 .865
  NON-MEL (n = 416) -1.46 (1.24) -1.40 (1.24) .474  
  Mean (SD)
PGI-Improvement MEL (n = 877) 2.67 (1.28) 2.64 (1.34) .484 .817
  NON-MEL (n = 416) 2.64 (1.29) 2.57 (1.02) .077  
  1. a. p-value for duloxetine vs. SSRI
  2. b. p-value for treatment-by-melancholia status interaction
  3. † Mean score (SD). Lower mean score indicates greater improvement.