Duloxetine in the treatment of Major Depressive Disorder: A comparison of efficacy in patients with and without melancholic features

Table 5 Mean changes from baseline to last observation in active comparator studies

	Melancholic Status	Mean Change (SD)		p-value^a	p-value^b
		Duloxetine	SSRI
HAMD ₁₇ Total Score	MEL (n = 878)	-8.85 (7.39)	-8.60 (7.68)	.709	.784
	NON-MEL (n = 416)	-8.18 (6.52)	-7.59 (6.70)	.897
CGI-Severity	MEL (n = 880)	-1.53 (1.26)	-1.52 (1.33)	.979	.865
	NON-MEL (n = 416)	-1.46 (1.24)	-1.40 (1.24)	.474
	Mean (SD)
PGI-Improvement ^†	MEL (n = 877)	2.67 (1.28)	2.64 (1.34)	.484	.817
	NON-MEL (n = 416)	2.64 (1.29)	2.57 (1.02)	.077

ISSN: 1471-244X