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Table 6 Mean changes from baseline to week 9 in melancholic patients (focus studies)

From: Duloxetine in the treatment of Major Depressive Disorder: A comparison of efficacy in patients with and without melancholic features

  Mean Change (SE) p-value
  Duloxetine 60 mg QD (n = 153) Placebo (n = 163)  
HAMD 17 Total Score -11.02 (0.65) -7.51 (0.61) <.001
Subscales    
   Maier -6.16 (0.36) -3.95 (0.34) <.001
   Anxiety -2.65 (0.22) -2.29 (0.21) .230
   Retardation -4.52 (0.26) -2.67 (0.24) <.001
   Sleep -1.78 (0.17) -1.17 (0.16) .007
VAS Overall Pain a -6.12 (-22.8) 0.13 (0.48) .002
CGI-Severity -1.84 (0.11) -1.30 (0.10) <.001
PGI-Improvement b 2.47 (0.11) 3.08 (0.11) <.001
  1. CGI = Clinical Global Impression; HAMD = Hamilton Rating Scale for Depression; PGI = Patient Global Impression
  2. a. Values are mean change (percentage mean change), and p value is from main effect of treatment
  3. b. Mean score (SE). Lower mean score indicates greater improvement.