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Table 2 Baseline characteristics of treatment groups

From: Quetiapine augmentation of SRIs in treatment refractory obsessive-compulsive disorder: a double-blind, randomised, placebo-controlled study [ISRCTN83050762]

Treatment Group   SRI baseline SRI Dose baseline (mg/day) Previous SRI trials Total YBOCS – Baseline Total YBOCS – Week 6 Endpoint dose (mg/day) % CHANGE CGI – Improvement Response status
Quetiapine 1 Paroxetine 60 1 33 29 50 -12.00 3 N/R
  2 Citalopram 60 2 25 23 200 -8.00 4 N/R
  3 Fluvoxamine 300 1 32 27 300 -16.00 3 N/R
  4 Citalopram 70 1 27 25 25 (E/W)* -7.00 4 N/R
  5 Clomipramine 250 2 22 27 100 23.00 5 N/R
  6 Paroxetine 60 5 35 32 300 -9.00 4 N/R
  7 Fluoxetine 80 3 25 16 300 -36.00 2 R
  8 Sertraline 200 1 18 3 50 -83.00 1 R
  9 Fluoxetine 20 1 21 20 300 -5.00 4 N/R
  10 Fluoxetine 60 1 22 17 300 -23.00 2 N/R
  11 Citalopram 60 1 32 17 300 -47.00 1 R
  12 Fluoxetine 80 1 32 14 300 -56.00 1 R
  13 Fluvoxamine 300 1 30 12 50 -60.00 1 R
  14 Fluoxetine 60 1 25 7 50 -72.00 1 R
  15 Citalopram 60 1 27 24 200 -11.00 4 N/R
  16 Fluvoxamine 300 1 24 12 150 -50.00 2 R
  17 Fluvoxamine 200 2 22 22 50 .00 4 N/R
  18 Fluvoxamine 300 2 25 22 25 -12.00 4 N/R
  19 Fluoxetine 60 2 24 25 25 (E/W)* 4.00 4 N/R
  20 Clomipramine 250 2 27 12 300 -56.00 2 R
Placebo 1 Fluvoxamine 300 2 32 25 300 -22.00 3 N/R
  2 Fluvoxamine 300 1 30 28 300 -7.00 3 N/R
  3 Fluoxetine 80 2 34 38 300 12.00 4 N/R
  4 Paroxetine 60 1 22 18 300 -18.00 1 N/R
  5 Citalopram 60 1 28 26 300 -7.00 4 N/R
  6 Fluoxetine 60 5 26 24 300 -8.00 3 N/R
  7 Fluoxetine 60 1 23 23 300 .00 4 N/R
  8 Fluoxetine 60 1 27 10 300 -63.00 1 R
  9 Fluoxetine 40 1 32 18 300 -44.00 2 R
  10 Citalopram 60 2 24 23 300 -4.00 4 N/R
  11 Citalopram 60 1 35 23 300 -34.00 2 R
  12 Fluvoxamine 300 3 22 14 300 -36.00 2 R
  13 Citalopram 60 1 28 10 50 -65.00 2 R
  14 Fluoxetine 60 1 28 4 50 -86.00 2 R
  15 Citalopram 60 1 26 19 100 -27.00 2 R
  16 Fluoxetine 60 1 27 12 100 -56.00 1 R
  17 Fluoxetine 20 1 26 18 200 -31.00 2 R
  18 Fluvoxamine 300 2 23 35 200 52.00 6 N/R
  19 Citalopram 60 2 26 9 100 -65.00 2 R
  20 Paroxetine 80 1 32 29 300 -9.00 3 N/R
  21 Fluvoxamine 300 3 31 25 100 -19.00 2 N/R
  1. *E/W = Early withdrawal