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Table 1 Selected studies presentation for duloxetine

From: Duloxetine compared with fluoxetine and venlafaxine: use of meta-regression analysis for indirect comparisons

Study

Inclusion criteria

Age

Percent male

Duration (weeks)

Treatment

Dosage (mg/day)

Patients per arm

Effect size (SD)

Response (%)

Dropouts (%)

Goldstein et al. [9]

DSM-IV, Age 18–65

HAM-D17 ≥ 15, CGI-S ≥ 4

42

0.34

8

Duloxetine

Placebo

40–120

70

70

-0.3(0.03)

0.64

0.48

0.34

0.34

Detke et al. [10]

DSM-IV, Age ≥ 18

HAM-D17 ≥ 15, CGI-S ≥ 4

42

0.33

9

Duloxetine

Placebo

60

123

122

-0.6(0.02)

0.62

0.29

 

Detke et al. [12]

DSM-IV, Age ≥ 18

HAM-D17 ≥ 15, CGI-S ≥ 4

41

0.31

9

Duloxetine

Placebo

60

128

139

-0.2(0.02)

0.65

0.42

0.39

0.35

Detke et al. [13]

DSM-IV, Age ≥ 18

HAM-D17 ≥ 15, CGI-S ≥ 4

45

43

0.26

0.25

8

Duloxetine

Duloxetine

Placebo

80

120

95

93

93

-0.3(0.02)

-0.6(0.02)

0.65

0.71

0.44

0.13

0.10

0.19

Goldstein et al. [14]

DSM-IV, Age ≥ 18

HAM-D17 ≥ 15, CGI-S ≥ 4

41

41

0.4

0.38

8

Duloxetine

Duloxetine

Placebo

40

80

86

91

89

-0.4(0.02)

-0.5(0.02)

0.54

0.60

0.30

0.36

0.42

0.42

Greist et al. [4]

Falissard et al. [3]

DSM-IV, Age ≥ 18

  

8

Duloxetine

Placebo

120

82

75

-0.1(0.03)

  

Greist et al. [4]

Falissard et al. [3]

DSM-IV, Age ≥ 18

  

8

Duloxetine

Duloxetine

Placebo

40

80

91

84

90

-0.2(0.02)

-0.4(0.02)

  

Greist et al. [4]

Falissard et al. [3]

DSM-IV, Age ≥ 18

  

8

Duloxetine

Duloxetine

Placebo

80

120

93

103

99

-0.3(0.02)

-0.3(0.02)

  

Brannan et al. [5]

DSM-IV, Age ≥ 18

HAM-D17 ≥ 15, CGI-S ≥ 4

41

0.35

9

Duloxetine

Placebo

60

141

141

-0.2(0.02)

0.42

0.40

0.16

0.09

Globally

 

42 (1)

0.33

8 (0.4)

Duloxetine

Placebo

20–120

1280

918

-0.29(0.05)

0.58(0.09) **

-0.02(0.16) **

  1. ** Log Odds ratios (SD)