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Table 1 Selected studies presentation for duloxetine

From: Duloxetine compared with fluoxetine and venlafaxine: use of meta-regression analysis for indirect comparisons

Study Inclusion criteria Age Percent male Duration (weeks) Treatment Dosage (mg/day) Patients per arm Effect size (SD) Response (%) Dropouts (%)
Goldstein et al. [9] DSM-IV, Age 18–65
HAM-D17 ≥ 15, CGI-S ≥ 4
42 0.34 8 Duloxetine
Placebo
40–120 70
70
-0.3(0.03) 0.64
0.48
0.34
0.34
Detke et al. [10] DSM-IV, Age ≥ 18
HAM-D17 ≥ 15, CGI-S ≥ 4
42 0.33 9 Duloxetine
Placebo
60 123
122
-0.6(0.02) 0.62
0.29
 
Detke et al. [12] DSM-IV, Age ≥ 18
HAM-D17 ≥ 15, CGI-S ≥ 4
41 0.31 9 Duloxetine
Placebo
60 128
139
-0.2(0.02) 0.65
0.42
0.39
0.35
Detke et al. [13] DSM-IV, Age ≥ 18
HAM-D17 ≥ 15, CGI-S ≥ 4
45
43
0.26
0.25
8 Duloxetine
Duloxetine
Placebo
80
120
95
93
93
-0.3(0.02)
-0.6(0.02)
0.65
0.71
0.44
0.13
0.10
0.19
Goldstein et al. [14] DSM-IV, Age ≥ 18
HAM-D17 ≥ 15, CGI-S ≥ 4
41
41
0.4
0.38
8 Duloxetine
Duloxetine
Placebo
40
80
86
91
89
-0.4(0.02)
-0.5(0.02)
0.54
0.60
0.30
0.36
0.42
0.42
Greist et al. [4]
Falissard et al. [3]
DSM-IV, Age ≥ 18    8 Duloxetine
Placebo
120 82
75
-0.1(0.03)   
Greist et al. [4]
Falissard et al. [3]
DSM-IV, Age ≥ 18    8 Duloxetine
Duloxetine
Placebo
40
80
91
84
90
-0.2(0.02)
-0.4(0.02)
  
Greist et al. [4]
Falissard et al. [3]
DSM-IV, Age ≥ 18    8 Duloxetine
Duloxetine
Placebo
80
120
93
103
99
-0.3(0.02)
-0.3(0.02)
  
Brannan et al. [5] DSM-IV, Age ≥ 18
HAM-D17 ≥ 15, CGI-S ≥ 4
41 0.35 9 Duloxetine
Placebo
60 141
141
-0.2(0.02) 0.42
0.40
0.16
0.09
Globally   42 (1) 0.33 8 (0.4) Duloxetine
Placebo
20–120 1280
918
-0.29(0.05) 0.58(0.09) ** -0.02(0.16) **
  1. ** Log Odds ratios (SD)