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Table 1 Predictors of patient satisfaction with antipsychotic medication

From: Reduction in psychotic symptoms as a predictor of patient satisfaction with antipsychotic medication in schizophrenia: Data from a randomized double-blind trial

 

Day 14

Day 42 (end point)

 

Univariate regression

Step-wise multiple regression R2 = .31

Univariate regression

Step-wise multiple regression R2 = .33

 

T =

p =

R2

F =

p =

T =

p =

R2

F =

p =

Symptom change PANSS factors Positive

-10.11

<.0001

.26

21.98

<.0001

-9.40

<.0001

.23

6.39

.01

Negative

-5.22

<.0001

.11

  

-5.69

<.0001

.12

3.63

.06

Disorganized thoughts

-5.89

<.0001

.13

  

-5.64

<.0001

.12

  

Hostility/excitement

-9.25

<.0001

.23

14.11

.0002

-8.69

<.0001

.21

12.46

.0005

Anxiety/depression

-5.80

<.0001

.13

4.03

.04

-7.43

<.0001

.17

16.85

<.0001

HAM-D

-5.33

<.0001

.11

 

NS

-5.06

<.0001

.11

 

NS

Adverse events Prolactin level

.439

.66

.04

  

-.666

.50

.04

 

NS

EPS reported

-.95

.34

.04

2.89

.09

.60

.55

.04

 

NS

Sedation reported

-1.21

.23

.05

  

1.91

.06

.05

 

NS

BAS global (present)

-1.42

.16

.05

  

-.88

.38

.04

  

SAS total (present)

-.50

.62

.04

  

-.25

.80

.04

  

Demographics Age

1.84

.07

.05

6.17

.01

.58

.56

.04

  

Gender (male)

.46

.64

.04

  

.37

.71

.04

  

Antipsychotic use

 

NA*

   

-2.69

.007

.06

8.03

.004

Risperidone

3.48

.0006

.04

4.80

.03

3.06

.002

 

4.94

.027

Quetiapine

1.15

.25

.04

.60

.44

.83

.41

 

.00

.98

  1. * Antipsychotic use appeals after 14 days.
  2. Abbreviations: PANSS, Positive and Negative Syndrome Scale; HAM-D, Hamilton Depression Scale; NS, not significant; EPS, extrapyramidal symptoms; BAS, Barnes Akathisia Scale; SAS, Simpson Angus Scale.