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Table 1 Predictors of patient satisfaction with antipsychotic medication

From: Reduction in psychotic symptoms as a predictor of patient satisfaction with antipsychotic medication in schizophrenia: Data from a randomized double-blind trial

  Day 14 Day 42 (end point)
  Univariate regression Step-wise multiple regression R2 = .31 Univariate regression Step-wise multiple regression R2 = .33
  T = p = R2 F = p = T = p = R2 F = p =
Symptom change PANSS factors Positive -10.11 <.0001 .26 21.98 <.0001 -9.40 <.0001 .23 6.39 .01
Negative -5.22 <.0001 .11    -5.69 <.0001 .12 3.63 .06
Disorganized thoughts -5.89 <.0001 .13    -5.64 <.0001 .12   
Hostility/excitement -9.25 <.0001 .23 14.11 .0002 -8.69 <.0001 .21 12.46 .0005
Anxiety/depression -5.80 <.0001 .13 4.03 .04 -7.43 <.0001 .17 16.85 <.0001
HAM-D -5.33 <.0001 .11   NS -5.06 <.0001 .11   NS
Adverse events Prolactin level .439 .66 .04    -.666 .50 .04   NS
EPS reported -.95 .34 .04 2.89 .09 .60 .55 .04   NS
Sedation reported -1.21 .23 .05    1.91 .06 .05   NS
BAS global (present) -1.42 .16 .05    -.88 .38 .04   
SAS total (present) -.50 .62 .04    -.25 .80 .04   
Demographics Age 1.84 .07 .05 6.17 .01 .58 .56 .04   
Gender (male) .46 .64 .04    .37 .71 .04   
Antipsychotic use   NA*     -2.69 .007 .06 8.03 .004
Risperidone 3.48 .0006 .04 4.80 .03 3.06 .002   4.94 .027
Quetiapine 1.15 .25 .04 .60 .44 .83 .41   .00 .98
  1. * Antipsychotic use appeals after 14 days.
  2. Abbreviations: PANSS, Positive and Negative Syndrome Scale; HAM-D, Hamilton Depression Scale; NS, not significant; EPS, extrapyramidal symptoms; BAS, Barnes Akathisia Scale; SAS, Simpson Angus Scale.