Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms

BMC Psychiatry

Table 3 Significant differences in GM volume between groups

BRAIN REGION	T	CLUSTER SIZE	MNI COORDINATES
Autism > Control
Frontal
Left medial frontal gyrus	3.43	1459	-8	41	54
Right medial frontal gyrus	3.08	160	15	58	32
Left pre-central gyrus	3.11	693	-37	-15	60
Temporal
Left middle temporal gyrus	3.24	1166	-50	-72	21
Right fusiform gyrus	3.09	354	38	-25	-28
Parietal
Right post-central gyrus	3.76	1155	50	-9	27
Subcortical
Left caudate nucleus	2.95	344	-13	21	-4
Right caudate nucleus	2.80	179	9	20	-3
Left hippocampus	3.48	274	-22	-28	-6
Autism < Control
Cerebellum
Left Cerebellar Crus I	3.33	11342	-46	-42	-31
Left Cerebellar Lobule VIII^†	2.77	299	-25	-48	-48
Left Cerebellar Lobule IX*	3.36	11342	-5	-59	-59
Right Cerebellar Crus I	3.38	2792	53	-54	-36

Notes: Regions reported in table are significant after small volume correction, p < .05. ^† Multiple foci are reported within the same structure when local maxima are greater than 12 mm apart. All labels are derived from AAL atlas (see text). * this maximum is near midline and the cluster has significant overlap with the cerebellar vermis. It also is contiguous with the left cerebellar crus I finding, which is why the cluster size for the two is reported as the same number. The cluster size is the number of contiguous voxels in the cluster at an uncorrected p < .01.

ISSN: 1471-244X