Skip to main content

Table 4 CES-D: Sensitivity analysis (SA) of 0–12 month outcomes

From: Anthroposophic therapy for chronic depression: a four-year prospective cohort study

Analysis N 0 months 12 months 0–12 month difference
   Mean SD Mean SD Mean SD P-value Median difference (95%-CI)
All patients enrolled in depression study          
Main analysis: enrolled patients with evaluable data at 0 and 12 months 75 34.77 (8.21) 19.55 (13.12) 15.23 (12.72) p < 0.001 15.50 (12.50–18.50)
SA1: last value carried forward 93 34.67 (7.95) 20.77 (12.56) 13.90 (12.29) p < 0.001 15.00 (12.00–17.50)
SA2: Patients with a disease duration of ≥ 24 months 61 35.10 (8.25) 21.05 (13.53) 14.05 (13.07) p < 0.001 14.50 (10.50–17.50)
SA3 Patients not using antidepressants or psychotherapy 39 33.03 (6.98) 17.74 (12.50) 15.29 (10.80) p < 0.001 15.50 (12.00–19.00)
SA1+SA2+SA3 33 33.27 (6.88) 19.33 (13.16) 13.94 (11.85) p < 0.001 14.00 (10.00–18.00)
AMOS patients screened for depression study after 1 Jan 2000*          
Main analysis: enrolled patients with evaluable data at 0 and 12 months 37 33.65 (7.64) 20.27 (13.07) 13.38 (11.98) p < 0.001 14.50 (9.50–17.50)
SA4: all screened patients (not enrolled + enrolled) with evaluable data at 0 and 12 months 57 28.35 (11.25) 18.53 (12.36) 9.82 (13.53) p < 0.001 10.00 (6.50–14.00)
SA1+SA2+SA4 58 29.36 (10.51) 20.72 (12.03) 8.64 (12.46) p < 0.001 9.50 (6.00–13.00)
  1. CES-D: Center for Epidemiological Studies Depression Scale, German version. AMOS: Anthroposophic Medicine Outcomes Study. *12-month follow-up documentation of CES-D was not performed for AMOS patients enrolled before 1 Jan 2000, except for patients also enrolled into depression study. **Percentage of patients improved from baseline. SRM: Standardised Response Mean effect size (small: 0.20–0.49, medium: 0.50–0.79, large: ≥ 0.80)