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Table 4 CES-D: Sensitivity analysis (SA) of 0–12 month outcomes

From: Anthroposophic therapy for chronic depression: a four-year prospective cohort study

Analysis

N

0 months

12 months

0–12 month difference

  

Mean

SD

Mean

SD

Mean

SD

P-value

Median difference (95%-CI)

All patients enrolled in depression study

         

Main analysis: enrolled patients with evaluable data at 0 and 12 months

75

34.77

(8.21)

19.55

(13.12)

15.23

(12.72)

p < 0.001

15.50 (12.50–18.50)

SA1: last value carried forward

93

34.67

(7.95)

20.77

(12.56)

13.90

(12.29)

p < 0.001

15.00 (12.00–17.50)

SA2: Patients with a disease duration of ≥ 24 months

61

35.10

(8.25)

21.05

(13.53)

14.05

(13.07)

p < 0.001

14.50 (10.50–17.50)

SA3 Patients not using antidepressants or psychotherapy

39

33.03

(6.98)

17.74

(12.50)

15.29

(10.80)

p < 0.001

15.50 (12.00–19.00)

SA1+SA2+SA3

33

33.27

(6.88)

19.33

(13.16)

13.94

(11.85)

p < 0.001

14.00 (10.00–18.00)

AMOS patients screened for depression study after 1 Jan 2000*

         

Main analysis: enrolled patients with evaluable data at 0 and 12 months

37

33.65

(7.64)

20.27

(13.07)

13.38

(11.98)

p < 0.001

14.50 (9.50–17.50)

SA4: all screened patients (not enrolled + enrolled) with evaluable data at 0 and 12 months

57

28.35

(11.25)

18.53

(12.36)

9.82

(13.53)

p < 0.001

10.00 (6.50–14.00)

SA1+SA2+SA4

58

29.36

(10.51)

20.72

(12.03)

8.64

(12.46)

p < 0.001

9.50 (6.00–13.00)

  1. CES-D: Center for Epidemiological Studies Depression Scale, German version. AMOS: Anthroposophic Medicine Outcomes Study. *12-month follow-up documentation of CES-D was not performed for AMOS patients enrolled before 1 Jan 2000, except for patients also enrolled into depression study. **Percentage of patients improved from baseline. SRM: Standardised Response Mean effect size (small: 0.20–0.49, medium: 0.50–0.79, large: ≥ 0.80)