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Table 1 SCID-I-II principal diagnosis of 183 healthy siblings, and SCID-I diagnosis of 111 individuals from the comparison group. In brackets number of those 14 siblings who had psychotic symptoms before 1991.

From: Psychosis among "healthy" siblings of schizophrenia patients

  Isolate siblings Comparison group
N 183 111
Psychotic disorders   
Schizophrenia 1 (1) 0.5% 1 0.9%
Schizoaffective disorder 6 (2) 3.3%  
Delusional disorder 3 (1) 1.6%  
Psychotic disorder NOS 8 (4) 4.4%  
Alcohol-induced psychotic disorders 4 (3) 2.2% 1 0.9%
Other substance-induced psychotic disorders 2 (1) 1.1%  
Major depressive disorder with psychotic features 4 (1) 2.2%  
Bipolar disorder I 2 (1) 1.1%  
Other mental disorders   
Other depressive disorders 28 15.3% 21 18.9%
Personality disorders A * 7 3.8% not assessed
Personality disorders B-C* 4 2.2% not assessed
Alcohol use disorders 7 3.8% 14 12.6%
Anxiety disorders 22 12.0% 8 7.2%
Other 1 0.5%  
Diagnosis 99 54.1% 45 40.5%
No diagnosis 84 45.9% 66 59.5%
Total 183 99.9% 111 100%
  1. *5 siblings had SCID-II personality disorder without other diagnosis.
  2. Siblings had 43 (23.5%) co-morbid diagnoses: 15 (8.2%) alcohol use, 15 anxiety (8.2%), and 6 (3.3%) other depressive disorders, 5 (2.7%) personality disorders (2 cluster A and 3 cluster B-C), one anxiolytic dependence disorder and one hypochondriasis. Comparison group had 10 (9.0%) co-morbid diagnoses: 5 anxiety and 5 alcohol use disorders.