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Table 5 Hazard ratios of time to medication discontinuation for atypical antipsychotics versus all typicals, versus perphenazine and versus haloperidol with prophylactic anticholinergics

From: Time to discontinuation of atypical versus typical antipsychotics in the naturalistic treatment of schizophrenia

Treatment groups

Hazard ratios (95% confidence interval)

Clozapine vs. All Typicals

3.51** (2.39, 5.18)

Olanzapine vs. All Typicals

1.74** (1.45, 2.08)

Risperidone vs. All Typicals

1.56** (1.29, 1.88)

Quetiapine vs. All Typicals

1.24** (0.97, 1.58)

Ziprasidone vs. All Typicals

0.84 (0.49, 1.44)

Clozapine vs. Perphenazine

3.25** (1.70, 6.21)

Olanzapine vs. Perphenazine

1.76** (1.15, 2.70)

Risperidone vs. Perphenazine

1.60* (1.04, 2.46)

Quetiapine vs. Perphenazine

1.06 (0.64, 1.77)

Ziprasidone vs. Perphenazine

0.76 (0.25, 2.33)

Clozapine vs. Haloperidol +

3.61** (2.26, 5.78)

Olanzapine vs. Haloperidol +

1.89** (1.43, 2.51)

Risperidone vs. Haloperidol +

1.71** (1.29, 2.25)

Quetiapine vs. Haloperidol +

1.33 (0.94, 1.88)

Ziprasidone vs. Haloperidol +

0.71 (0.32, 1.58)

  1. Abbreviations: Haloperidol + denotes the use of haloperidol with prophylactic anticholinergic agent.
  2. Prophylactic use of anticholinergics is defined as a prescription for haloperidol and an anticholinergic on the date haloperidol was initiated, or 1 day later.
  3. *Significant at p < 0.05 level
  4. **Significant at p ≤ 0.01 level
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BMC Psychiatry

ISSN: 1471-244X

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