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Table 1 Microsatellite haplotypes observed in exon 11 missense variant carriers.

From: The NRG1 exon 11 missense variant is not associated with autism in the Central Valley of Costa Rica

Family ID

A/B/C/D

487-2

D8S1810

420M9-1395

317J8-2123

Exon 11 G>T

T/NT

Hap#

Comment

AU025

25B

247.5

194

190

240

T

NT

1

 

AU025

25C

235.7

192

202

247

T

NT

2

Sister with bipolar disorder

AU027

27C

247.5

194

(190)

246

T

NT

3

Possible extended hap

AU044

44C

247.5

(194)

190

246

T

NT

3

Possible extended hap

AU058

58A

245.7

176

181

247

T

T

2

 

AU058

58C

245.7

176

181

247

T

T

2

 

AU058

58D2

245.7

176

181

247

T

T

2

 

AU059

59A

235.7

196

202

242

T

T

4

 

AU059

59C

235.7

196

202

242

T

T

4

 

AU061

61B

237.7

178

181

242

T

NT

4

Extended hap

AU071

71B

237.7

178

181

242

T

NT

4

Extended hap

AU090

90A

237.7

178

181

242

T

T

4

Extended hap

AU090

90C

237.7

178

181

242

T

T

4

 

AU089

89C

246.4

176

181

242

T

NT

4

Extended hap w recomb?

AU113

113C

253.1

178

186

242

T

NT

4

Brother with SCZ

AU129

129A

235.7

194

202

246

T

NT

3

De novo in case

AU143

143B

243.8

194

202

253

T

NT

5

 

AU164

164B

241.8

178

186

253

T

NT

5

 

AU165

165B

239.7

196

190

238

T

NT

6

 
  1. The first column contains the family ID number of the autism proband. The second column indicates the family member status, for example 25A signifies the case, 25B signifies the father, 25C signifies the mother and 58D2 indicates the second sibling of case 58. The next 4 columns contain alleles from the 4 microsatellites genotyped to determine which haplotypes are associated with the rare 'T' allele. Alleles were binned where possible with the exception of marker 478–642 wherein the allele is called as reported by the software. Brackets around an allele mean that phase could not be determined with certainty. The "T/NT" column indicates whether the haplotype was transmitted, or not transmitted, from a parent to a case, or the sibling of a case. The "Hap#" column indicates the number of different haplotype backgrounds associated with the 'T' allele considering only the closest microsatellite 317J8-2123 (0.229 Mb away). The comment column notes extended haplotypes > ~1 Mb A question mark next to the haplotype number indicates that the haplotype background could not be determined with certainty.