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Table 1 Microsatellite haplotypes observed in exon 11 missense variant carriers.

From: The NRG1 exon 11 missense variant is not associated with autism in the Central Valley of Costa Rica

Family ID A/B/C/D 487-2 D8S1810 420M9-1395 317J8-2123 Exon 11 G>T T/NT Hap# Comment
AU025 25B 247.5 194 190 240 T NT 1  
AU025 25C 235.7 192 202 247 T NT 2 Sister with bipolar disorder
AU027 27C 247.5 194 (190) 246 T NT 3 Possible extended hap
AU044 44C 247.5 (194) 190 246 T NT 3 Possible extended hap
AU058 58A 245.7 176 181 247 T T 2  
AU058 58C 245.7 176 181 247 T T 2  
AU058 58D2 245.7 176 181 247 T T 2  
AU059 59A 235.7 196 202 242 T T 4  
AU059 59C 235.7 196 202 242 T T 4  
AU061 61B 237.7 178 181 242 T NT 4 Extended hap
AU071 71B 237.7 178 181 242 T NT 4 Extended hap
AU090 90A 237.7 178 181 242 T T 4 Extended hap
AU090 90C 237.7 178 181 242 T T 4  
AU089 89C 246.4 176 181 242 T NT 4 Extended hap w recomb?
AU113 113C 253.1 178 186 242 T NT 4 Brother with SCZ
AU129 129A 235.7 194 202 246 T NT 3 De novo in case
AU143 143B 243.8 194 202 253 T NT 5  
AU164 164B 241.8 178 186 253 T NT 5  
AU165 165B 239.7 196 190 238 T NT 6  
  1. The first column contains the family ID number of the autism proband. The second column indicates the family member status, for example 25A signifies the case, 25B signifies the father, 25C signifies the mother and 58D2 indicates the second sibling of case 58. The next 4 columns contain alleles from the 4 microsatellites genotyped to determine which haplotypes are associated with the rare 'T' allele. Alleles were binned where possible with the exception of marker 478–642 wherein the allele is called as reported by the software. Brackets around an allele mean that phase could not be determined with certainty. The "T/NT" column indicates whether the haplotype was transmitted, or not transmitted, from a parent to a case, or the sibling of a case. The "Hap#" column indicates the number of different haplotype backgrounds associated with the 'T' allele considering only the closest microsatellite 317J8-2123 (0.229 Mb away). The comment column notes extended haplotypes > ~1 Mb A question mark next to the haplotype number indicates that the haplotype background could not be determined with certainty.