Table 2 Outcomes for placeo controlled trials in bipolar depression [18, 20, 22] – efficacy and discontinuations in trials lasting 8 weeks

Efficacy

1

108/355

39

30

1.3 (1.04 to 1.6)

11.6 (6.4 to 62)

2

313/330

58

40

1.5 (1.3 to 1.7)

5.4 (4.2 to 7.7)

3

240/685

52

35

1.4 (1.2 to 1.6)

6.0 (4.8 to 7.7)

1

87/355

33

25

1.3 (1.06 to 1.7)

12.1 (6.7 to 62)

2

96/330

52

29

1.8 (1.5 to 2.2)

4.3 (3.5 to 5.9)

3

183/685

46

27

1.6 (1.3 to 1.9)

5.3 (4.3 to 7.0)

1

23/345

6

7

0.8 (0.5 to 1.5)

not calculated

2

18/347

5

3

0.6 (0.4 to 1.2)

not calculated

3

41/692

4

6

0.7 (0.5 to 1.1)

not calculated

Discontinuations

1

232/355

54

65

0.8 (0.7 to 0.9)

9.1 (5.5 to 27)

2

132/349

38

42

1.1 (0.8 to 1.3)

not calculated

3

364/704

46

52

0.9 (0.8 to 1.05)

17 (10 to 50)

1

121/355

21

34

0.6 (0.5 to 0.8)

7.5 (5.1 to 15)

2

37/349

2

11

0.2 (0.1 to 0.3)

11 (7.7 to 20)

3

158/704

8

22

0.5 (0.4 to 0.6)

7.0 (5.6 to 10)

1

19/355

10

5

1.8 (1.1 to 3.1)

23 (12 to 220)

2

17/349

16

5

3.2 (2.0 to 5.2)

9.4 (6.7 to 14)

3

36/704

14

5

2.6 (1.8 to 3.7)

12 (10 to 14)