Skip to main content

Table 5 Outcomes in maintenance trials in bipolar mania – efficacy and discontinuations in trials lasting 26 weeks or longer [vs placebo 46. 48, 49 versus active 45, 47]

From: Atypical antipsychotics in bipolar disorder: systematic review of randomised trials

   Events/total patients Event rate (%)   
Outcome Trials Treatment Active control Treatment Active control Relative Risk (95% CI) NNTp or NNH (95% CI)
Relapse        
Any relapse        
All versus placebo 3 135/332 166/257 41 65 0.6 (0.5 to 0.7) 4.2 (3.1 to 6.2)
Olanzapine versus placebo 2 116/255 130/174 45 75 0.6 (0.5 to 0.7) 3.4 (2.6 to 4.9)
Olanzapine versus active 2 79/250 96/237 32 41 0.8 (0.6 to 0.98) 11 (5.7 to 250)
Depressive relapse        
All versus placebo 3 84/332 79/257 25 31 0.8 (0.6 to 0.98) 18 (7.8 to 18)
Olanzapine versus placebo 2 75/255 68/174 29 39 0.7 (0.6 to 0.97) 10 (5.3 to 200)
Manic relapse        
All versus placebo 3 39/332 74/257 12 29 0.4 (0.3 to 0.6) 5.9 (4.2 to 9.5)
Olanzapine versus placebo 2 33/255 55/174 13 32 0.4 (0.3 to 0.6) 5.4 (3.7 to 9.4)
Discontinuation        
All cause        
All versus placebo 3 146/354 116/267 41 43 1.1 (0.9 to 1.3) not calculated
Olanzapine versus placebo 2 107/276 61/184 39 33 1.3 (1.04 to 1.7) 18 (6.9 to 30)
Olanzapine versus active 2 222/342 250/341 65 73 0.9 (0.8 to 0.98) 12 (6.5 to 67)
Lack of efficacy        
All versus placebo 3 36/354 55/267 10 21 0.6 (0.5 to 0.9) 9.6 (6.2 to 22)
Olanzapine versus placebo 2 17/276 19/184 6 10 0.8 (0.4 to 1.4) not calculated
Olanzapine versus active 2 55/342 62/340 16 18 0.9 (0.6 to 1.2) not calculated
Adverse events        
All versus placebo 3 27/354 9/267 8 4 2.4 (1.1 to 5.0) 24 (13 to 160)
Olanzapine versus placebo 2 22/276 8/184 8 5 2.0 (0.9 to 4.5) not calculated
Olanzapine versus active 2 72/342 80/340 21 24 0.9 (0.7 to 1.2) not calculated
  1. For discontinuations NNTp is shown in bold, indicating fewer events with treatment than placebo. More events with treatment than placebo, NNH, is in plain text. Active comparators were haloperidol, lithium, or divalproex