Skip to main content

Advertisement

Table 1 Depression incidence for four hypnotics and parallel placebos

From: Greater incidence of depression with hypnotic use than with placebo

Drug N subjects Depression incidence
Zolpidem 353 6
Zolpidem placebo 377 2
Eszopiclone 802 32
Eszopiclone placebo 294 3
Zaleplon 786 24
Zaleplon placebo 277 6
Ramelteon 3594 48
Ramelteon placebo 1370 11
Total of 4 hypnotics 5535* 110 (2.0%)*
Total of 4 placebo groups 2318* 22 (0.9%)*
  1. *Chi Square = 10.04, p < 0.002, risk ratio = 2.1