Skip to main content

Table 1 Depression incidence for four hypnotics and parallel placebos

From: Greater incidence of depression with hypnotic use than with placebo

Drug

N subjects

Depression incidence

Zolpidem

353

6

Zolpidem placebo

377

2

Eszopiclone

802

32

Eszopiclone placebo

294

3

Zaleplon

786

24

Zaleplon placebo

277

6

Ramelteon

3594

48

Ramelteon placebo

1370

11

Total of 4 hypnotics

5535*

110 (2.0%)*

Total of 4 placebo groups

2318*

22 (0.9%)*

  1. *Chi Square = 10.04, p < 0.002, risk ratio = 2.1