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Table 2 Messenger RNA levels of immune response and oligodendrocyte related genes in frontal cortex of schizophrenic subjects as compared to control individuals, quantified by qPCR

From: Inflammation-related genes up-regulated in schizophrenia brains

 

Fold change

F-ratio

Gene

Schizo

(n = 55)

NTD

(n = 11)

Typical

(n = 7)

Atypical

(n = 7)

Schizo vs. Ctrl

Subgroup

SERPINA3

3.6

4.4

2.2

7.6

20.7

***

1.8

 

IFITM2

1.4

1.7

1.3

1.6

16.2

***

1.8

 

IFITM3

1.4

1.7

1.2

1.5

16.3

***

2.7

 

GBP1

1.5

1.6

1.6

2.0

6.9

**

0.1

 

HLA-A

1.2

1.0

1.3

1.2

2.6

 

1.0

 

MAG

-1.7

-1.8

-1.4

-3.5

9.5

**

2.2

 

SCD

-1.2

-1.5

1.1

-2.1

3.3

 

6.9

**

TF

-1.4

-1.9

1.1

-3.2

5.1

*

7.9

***

  1. Schizophrenic patients have been subdivided according to the antipsychotic medication received at death. Mean levels across all schizophrenic subjects are compared to controls individuals (Schizo vs. Ctrl), and the heterogeneity between the three subgroups is tested (Subgroup). Asterisk (*) indicates statistically significant deviation from the null hypothesis (p-value <0.05, <0.01 and <0.001 for one, two and three asterisks, respectively).
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BMC Psychiatry

ISSN: 1471-244X

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