From: Evaluating dose response from flexible dose clinical trials
Predictors of dose level during visit interval (adjusted for previous dose level) | Study A | Study B | ||
---|---|---|---|---|
odds ratio* (95% CI) | p-value | odds ratio* (95% CI) | p-value | |
YMRS** (Study A) or PANSS** (Study B) reduction from baseline to the end of previous visit interval | 0.88 (0.86, 090) | < .0001 | 0.97 (0.96–0.99) | <.0001 |
Adverse event (AE) indicator (max severity score during previous visit interval) | 0.87 (0.74–1.01) | .075 | 1.02 (.78–1.33) | ns |
Baseline YMRS** (Study A) or PANSS** (Study B) total score | 1.14 (1.10, 1.18) | < .0001 | 1.04 (1.02–1.05) | <.0001 |