From: Effectiveness of second generation antipsychotics: A systematic review of randomized trials
Studies | Main results (rating scales/outcome measures) |
---|---|
FIRST EPISODE | |
Crespo-Facorro et al. [24] | O = R = H (CGI-S, BPRS, SAPS, SANS, HAM-D, CDS, YMRS, response 1 rate, mean time to response) |
McEvoy et al. [25] | O = Q = R (PANSS total change) O > Q (PANSS positive subscale reduction) (p = 0.013) O = Q = R (response rate 2) |
Robinson et al. [26] | O = R (cumulative response 3 rates, mean time to response) O = R (delusions, hallusinations, thought disorders (SADS-C+PD positive symptoms items); affective flattening, alogia, avolition-apathy, asociality-anhedonia (SANS)) R > O (mean length of time that subjects maintained the of responder status) (CI= 8.6-10.4 vs. 5.6-7.7) |
ACUTE PHASE | |
Chrzanowski et al. [27] | A = O (PANSS, CGI-I) |
Kraus et al. [28] | No outcomes |
McCue et al. [29] | A = H = O = Q = R = Z (BPRS change) |
CHRONIC PHASE | |
Jerrel [30] | O = R = FGA (PANSS, BPRS, DIS-III-R Depression and Mania symptoms) |
Lieberman et al. [31] | O = P = Q = R = Z (PANSS, CGI) O > Q (p < 0.001) & R (p = 0.002) & P (p = 0.013) (duration of successful treatment 4) R > Q (duration of successful treatment) (p = 002) |
Mullen et al. [32] | Q = R (PANSS) Q > R (HAM-D) (p = 0.028) Q = R (CGI-I) |
Ritchie et al. [33] | O = R (BPRS, SANS, MADRS, MMSE) |
Ritchie et al. [34] | O = R (BPRS, SANS, MADRS, MMSE) |
Rosenheck et al. [35] | O = P = Q = R = Z (PANSS) |
Stroup et al. [36] | O > Q (p = 0.005) & Z (p = 0.005) (PANSS) O > Q (p < 0.001) & Z (p < 0.001) & R (p < 0.02) (PANSS positive symptoms) R > Z (p < 0.03) (PANSS positive symptoms) O = Q = R = Z (CGI) |
Stroup et al. [37] | O = Q = R (PANSS) O = Q = R (CGI at endpoint) |
Swartz et al. [38] | No outcomes |
Tunis et al. [39] | O > FGA (mean clinical responder days 5) (p = 0.025) |