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Table 5 Concomitant medication

From: Effectiveness of second generation antipsychotics: A systematic review of randomized trials

Studies Comparators
FIRST EPISODE  
Crespo-Facorro et al. [24] H = O = R (benzodiazepines for anxiety/agitation or EPS; hypnotics)
H > R > O (anticholinergics for EPS) (p < 0.0001)
McEvoy et al. [25] O = Q = R (postbaseline adjunctive medication use for dysphoria/depression, anxiety, insomnia, agitation/excitement)
O > Q (proportion receiving concomitant medications for parkinsonism or akathisia) (p = 0.021)
Robinson et al. [26] O = R (divalproex, sertraline, benztropin, propranolol, lorazepam)
ACUTE PHASE  
Chrzanowski et al. [27] A = O (anticholinergics)
Kraus et al.* [28] O = R (benztropine and/or trihexyphenidyl, mood-stabilizers, antidepressants, haloperidol, quetiapine, ziprasidone, perphenazine, lorazepam and/or clonazepam)
R > O (diphenhydramine and/or hydroxyzine) (p = 0.05)
McCue et al. * [29] A = H = O = Q = R = Z (dosages of additional: haloperidol, lorazepam, benzatropine)
A = H = O = Q = R = Z (patients receiving additional: mood stabiliser, antidepressant, anxiolytic)
A > Q > R > Z > H > O (dosage of diphenhydramine) (p = 0.004)
H > R > Q = Z > A = O (patients receiving anticholinergics) (p < 0.0001)
CHRONIC PHASE  
Jerrel * [30] O & R > FGA (odds of being prescribed mood-stabilizers or supplemental antipsychotics) (p < 0.001)
Lieberman et al. [31] O = P = Q = R = Z (lithium, anticonvulsants, oral glucose-lowering drugs, insulin, cholestatin drugs)
R > Z > O > P > Q (antidepressants) (p = 0.03)
R = P = Z > O > Q (hypnotics, sedatives) (p = 0.03)
P = Z > Q > R > O (anxiolytics) (p < 0.001)
P > R > Z > O > Q (anticholinergics agents) (p = 0.01)
Mullen et al.* [32] Not disclosed
Ritchie et al. [33] Not disclosed
Ritchie et al. [34] Not disclosed
Rosenheck et al. [35] Not disclosed
Stroup et al. [36] O = Q = R = Z (details not disclosed)
Stroup et al. [37] O = Q = R (lithium, anticonvulsants, antidepressants, hypnotic, sedatives, anxiolytics, anticholinergics, oral glucose-lowering drugs and insulin, cholestatin drugs)
Swartz et al. [38] Not disclosed
Tunis et al. [39] Details not disclosed
  1. Abbreviations: A = Aripiprazole, FGAs = First generation antipsychotics, O = Olanzapine, P = Perphenazine, Q = Quetiapine, R = Risperidone, Z = Ziprasidone, EPS = the extrapyramidal syndrome, * = Additional antipsychotics permitted.