Figure 2

Clusters with individual patient response profiles. Individual patient response profiles within each cluster. Colors within each profile were assigned as follows: "magenta" for all time points starting when sustained relapse criterion was first met (YMRS total ≥ 15) until week 7 or discontinuation; "green" for all time points starting when sustained remission criterion was first met (YMRS total ≤ 12) until week 7 or discontinuation; "light blue" for all the time points when neither sustained relapse nor remission criterion were met. Horizontal lines indicate the cut-offs for relapse (red) and remission (black). The dark blue line represents the mean response. A. Cluster 1 patients (n = 64) showing slower response, most of whom had a sustained relapse (magenta lines) or did not meet relapse or remission criteria (blue lines). B. Cluster 2 patients (n = 92) showing rapid early improvement, and most of them had a sustained remission (green lines). C. Cluster 3 patients (n = 36) showing rapid early improvement, then most subsequently relapsed (magenta lines). D. Cluster 4 patients (n = 30) showing slower response, and most of them had a sustained remission (green lines).