TY - JOUR AU - Chaput, Yves AU - Magnan, Annick AU - Gendron, Alain PY - 2008 DA - 2008/08/28 TI - The co-administration of quetiapine or placebo to cognitive-behavior therapy in treatment refractory depression: A preliminary trial JO - BMC Psychiatry SP - 73 VL - 8 IS - 1 AB - Patients with major depression refractory to repeated pharmacological trials (TRD) may remain symptomatic for many years after their index episode. Augmentation strategies (with lithium or an atypical antipsychotic) or combining an antidepressant with short-term psychotherapy have been used with relative success in these patients. The aim of this study was to assess the effectiveness of the concomitant administration of quetiapine, an atypical antipsychotic, or placebo, to cognitive-behavior therapy (CBT) in TRD. SN - 1471-244X UR - https://doi.org/10.1186/1471-244X-8-73 DO - 10.1186/1471-244X-8-73 ID - Chaput2008 ER -