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Table 1 TDT Analysis of candidate genes for pediatric bipolar disorder

From: Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children

Gene Marker Allele1 Frequency T:U2 OR 95% CI χ2 (1) p-value
BDNF Val66Met Val66 0.85 43:35 1.23 0.79–1.92 0.8 0.37
COMT Val158Met COMT-l 0.50 85:67 1.27 0.92–1.75 2.1 0.14
SLC6A4 HTTLPR Short 0.46 73:84 0.87 0.63–1.19 0.8 0.38
  1. T:U (trasmitted:untransmitted counts from basic TDT); OR 95% CI (odds ratio and 95% confidence interval from basic TDT. 1 Val66 (G allele at rs6265), COMT-L (Met158; A allele at rs4680), Short (14-repeat allele). 2 76 parents were heterozygous for the BDNF Val66 allele, 142 parents were heterozygous for the COMT-l allele, and 146 parents were heterozygous for the SLC6A4 short allele.