Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children

Table 1 TDT Analysis of candidate genes for pediatric bipolar disorder

Gene	Marker	Allele¹	Frequency	T:U²	OR	95% CI	χ² ₍₁₎	p-value
BDNF	Val66Met	Val66	0.85	43:35	1.23	0.79–1.92	0.8	0.37
COMT	Val158Met	COMT-l	0.50	85:67	1.27	0.92–1.75	2.1	0.14
SLC6A4	HTTLPR	Short	0.46	73:84	0.87	0.63–1.19	0.8	0.38

T:U (trasmitted:untransmitted counts from basic TDT); OR 95% CI (odds ratio and 95% confidence interval from basic TDT. ¹ Val66 (G allele at rs6265), COMT-L (Met158; A allele at rs4680), Short (14-repeat allele). ² 76 parents were heterozygous for the BDNF Val66 allele, 142 parents were heterozygous for the COMT-l allele, and 146 parents were heterozygous for the SLC6A4 short allele.

ISSN: 1471-244X