Treatment of schizophrenia with antipsychotics in Norwegian emergency wards, a cross-sectional national study

BMC Psychiatry

Table 1 Antipsychotic equivalent doses and Defined Daily Doses of common antipsychotics.

FGA
Drug	Potency Ratio	Antipsychotic equivalent doses.	DDD⁵ (mg)	Adm-route
Low-potency
Chlorpromazine (Largactil^®)	1.0	300.0	300.0	O
Klorprotixene (Truxal ^®)	2.0	150.0²	300.0	O
Levomepromazine (Nozinan^®)	1.0	300.0⁵	300.0	O
Thioridazine (Melleril^®)	1.0	300.0¹	300.0	O
Medium potency
Dixyrazine (Esucos^®)	6.0	50.0⁵	50.0	O
Perphenazine (Trilafon^®)	12.5	24.0¹	30.0	O
Perphenazine decanoate (Trilafon depot^®)	53.0	5.7⁵	7.0	P
Prochlorperazine (Stemetil^®)	6.7	45.0¹	100.0	O
Zuclopenthixol (Cisordinol^®)	4.0	75.0¹	30.0	O
Zuclopenthixol decanoate (Cisordinol Depot^®)	7.0	42.0¹	15.0	P
High-potency
Flupenthixol (Fluanxol^®)	50.0	6.0¹	6.0	O
Flupenthixol decanoate (Fluanxol depot^®)	70.0	4.2¹ ⁴	4.0	P
Haloperidol (Haldol^®)	33.0	9.0¹	8.0	O
Haloperidol decanoate (Haldol depot^®)	50.0	6.0¹ ⁴	3.3	P
SGA
Amisulpride (Solian^®)	1.0	300.0¹	400.0	O
Aripiprazole (Abilify^®)	13.3	22.5³	15.0	O
Clozapine (Leponex^®, Clozapine^®)	1.0	300.0¹	300.0	O
Olanzapine (Zyprexa^®)	20.0	15.0³	10.0	O
Quetiapine (Seroquel^®)	1.3	225.0³	400.0	O
Risperidone (Risperdal^®)	66.0	4.5¹	5.0	O
Risperidone long-acting injection (Risperdal Consta^®)	100.0	3.0⁶	1.8	P
Sertindole (Serdolect^®)	18.8	16.0⁵	16.0	O
Ziprazidone (Zeldox^®)	1.6	180.0³	80.0	O

¹Bazire, S. (2005) Psychotropic Drug Directory 2005. [18]
²Davis, J. M. (1974) Dose equivalence of the antipsychotic drugs. J. Psychiatr. Res., 11, 65–69[19]
³Woods, S. W. (2003) Chlorpromazine equivalent doses for the newer atypical antipsychotics. J. Clin. Psychiatry, 64, 663–667. [20]
⁴Kane, J. M., Aguglia, E., Altamura, A. C., et al (1998) Guidelines for depot antipsychotic treatment in schizophrenia. European Neuropsychopharmacology Consensus Conference in Siena, Italy. Eur. Neuropsychopharmacol., 8, 55–66. [21]
⁵WHO Collaborating Centre for Drug Statistics Methodology (2005) ATC Index with DDDs. [22]
⁶ Bai YM et al, Equivalent Switching Dose From Oral Risperidone to Risperidone Long-Acting Injection: A 48-Week Randomized, Prospective, Single-Blind Pharmacokinetic Study. J Clin Psychiatry 2007;68:1218–1225. [24].
⁷Administration Route: O: oral, P: peroral.
The chlorpromazine equivalent doses of levomepromazine, dixyrazine, sertindol and perphenazine decanoate are not adequately defined in the literature, and chlorpromazine equivalent dose is calculated from the DDD.

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