Persistence and compliance to antidepressant treatment in patients with depression: A chart review

BMC Psychiatry

Table 1 Persistence Rates and Clinical Characteristics

	Persistence Rate (%)
Baseline	Month 1	Month 3	Month 6
Any antidepressant (n = 367)	72.8	54.0	44.3
Initial antidepressant	66.1	43.3	31.3
Sulpiride (n = 148)	70.9	48.6	35.1
Paroxetine (n = 114)	58.8	36.0	28.1
Fluvoxamine (n = 34)	60.6	29.4	20.6
Sertraline (n = 33)	75.8	51.5	51.5^a
Milnacipran (n = 31)	67.7	51.6	19.4
Amoxapine (n = 5)	80.0	60.0	20.0
Trazodone (n = 2)	0.0	0.0	0.0
	Persistence Rate to Any Antidepressant (%)
Sex
Female (n = 197)	64.4	49.2	40.6
Male (n = 170)	82.3 ^b	59.4	47.6
Age groups
Before age 40 (n = 241)	72.6	50.6	41.7
40–59 (n = 95)	75.8	61.1	44.2
60 or older (n = 31)	64.5	58.1	58.1
Anxiolytics use
No (n = 245)	68.2	51.8	41.6
Yes (n = 122)	82.0 ^c	58.2	48.4
Hypnotics use
No (n = 191)	70.2	50.1	40.8
Yes (n = 176)	75.6	49.7	47.2

^a Logistic regression analysis found that sertraline use was associated with persistence to an initial antidepressant at month 6 (odds ratio = 2.59 in comparison with sulpiride, 95% CI = 1.16–5.77, p = 0.020).
^b Male gender was associated with persistence to any antidepressant drug at month 1 (odds ratio = 2.37, 95% CI = 1.44–3.90, p = 0.001)
^c The use of benzodiazepine-derivative anxiolytics also had a positive effect on the persistence to any antidepressant at month 1 (odds ratio = 2.14, 95% CI = 1.22–3.73, p = 0.008).

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