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Table 1 Persistence Rates and Clinical Characteristics

From: Persistence and compliance to antidepressant treatment in patients with depression: A chart review

  Persistence Rate (%)
Baseline Month 1 Month 3 Month 6
Any antidepressant (n = 367) 72.8 54.0 44.3
Initial antidepressant 66.1 43.3 31.3
   Sulpiride (n = 148) 70.9 48.6 35.1
   Paroxetine (n = 114) 58.8 36.0 28.1
   Fluvoxamine (n = 34) 60.6 29.4 20.6
   Sertraline (n = 33) 75.8 51.5 51.5a
   Milnacipran (n = 31) 67.7 51.6 19.4
   Amoxapine (n = 5) 80.0 60.0 20.0
   Trazodone (n = 2) 0.0 0.0 0.0
  Persistence Rate to Any Antidepressant (%)
Sex    
   Female (n = 197) 64.4 49.2 40.6
   Male (n = 170) 82.3 b 59.4 47.6
Age groups    
   Before age 40 (n = 241) 72.6 50.6 41.7
   40–59 (n = 95) 75.8 61.1 44.2
   60 or older (n = 31) 64.5 58.1 58.1
Anxiolytics use    
   No (n = 245) 68.2 51.8 41.6
   Yes (n = 122) 82.0 c 58.2 48.4
Hypnotics use    
   No (n = 191) 70.2 50.1 40.8
   Yes (n = 176) 75.6 49.7 47.2
  1. a Logistic regression analysis found that sertraline use was associated with persistence to an initial antidepressant at month 6 (odds ratio = 2.59 in comparison with sulpiride, 95% CI = 1.16–5.77, p = 0.020).
  2. b Male gender was associated with persistence to any antidepressant drug at month 1 (odds ratio = 2.37, 95% CI = 1.44–3.90, p = 0.001)
  3. c The use of benzodiazepine-derivative anxiolytics also had a positive effect on the persistence to any antidepressant at month 1 (odds ratio = 2.14, 95% CI = 1.22–3.73, p = 0.008).