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Table 2 Clinical Characteristics Associated with Higher Persistence

From: Persistence and compliance to antidepressant treatment in patients with depression: A chart review

  Odds Ratio (95% CI; p value)
  Persistence to Initial Antidepressant
  Month 1 a Month 3 b Month 6 c
   Sulpiride (n = 148) 1.00 (reference) 1.00 (reference) 1.00 (reference)
   Paroxetine (n = 114) 0.60
(0.34–1.06; p = 0.08)
0.61
(0.36–1.04; p = 0.07)
0.76
(0.43–1.34; p = 0.35)
   Fluvoxamine (n = 34) 0.80
(0.35–1.82; p = 0.59)
0.49
(0.21–1.12; p = 0.09)
0.59
(0.23–1.49; p = 0.27)
   Sertraline (n = 33) 1.68
(0.67–4.18; p = 0.27)
1.32
(0.60–2.91; p = 0.49)
2.59
(1.16–5.77; p = 0.02)
   Milnacipran (n = 31) 1.13
(0.47–2.71; p = 0.78)
1.40
(0.63–3.13; p = 0.41)
0.56
(0.21–1.49; p = 0.25)
   Amoxapine (n = 5) 0.00
(0.0-0.0; p = 0.99)
0.00
(0.0-0.0; p = 0.99)
0.00
(0.0-0.0; p = 0.99)
   Trazodone (n = 2) 1.13
(0.12–11.1; p = 0.92)
1.13
(0.18–7.35; p = 0.90)
0.33
(0.03–3.28; p = 0.35)
  Persistence to Any Antidepressant
  Month 1d Month 3 e Month 6 f
Sex    
   Female (n = 197) 1.00 (reference) 1.00 (reference) 1.00 (reference)
   Male (n = 170) 2.37
(1.44–3.90; p = 0.001)
1.42
(0.93–2.17; p = 0.10)
1.29
(0.84–1.97; p = 0.24)
Age groups    
   Before age 40 (n = 241) 1.00 (reference) 1.00 (reference) 1.00 (reference)
   40–59 (n = 95) 1.01
(0.57–1.79; p = 0.97)
1.43
(0.87–2.33; p = 0.16)
1.02
(0.62–1.66; p = 0.95)
   60 or older (n = 31) 0.70
(0.31–1.59; p = 0.40)
1.38
(0.65–2.96; p = 0.41)
1.96
(0.91–4.21; p = 0.08)
Anxiolytics use    
   No (n = 245) 1.00 (reference) 1.00 (reference) 1.00 (reference)
   Yes (n = 122) 2.14
(1.22–3.73, p = 0.008)
1.30
(0.82–2.04, p = 0.27)
1.38
(0.87–2.17, p = 0.17)
Hypnotics use    
   No (n = 191) 1.00 (reference) 1.00 (reference) 1.00 (reference)
   Yes (n = 176) 1.44
(0.88–2.36, p = 0.15)
1.24
(0.81–1.90, p = 0.33)
1.35
(0.87–2.17, p = 0.17)
  1. Underlined figures represent statistically significant values.
  2. a Model statistics: χ2 [11] = 36.0 (p < 0.001); Nagelkerke R2 = 0.13
  3. b Model statistics: χ2 [11] = 23.8 (p = 0.014); Nagelkerke R2 = 0.084
  4. c Model statistics: χ2 [11] = 25.8 (p = 0.007); Nagelkerke R2 = 0.095
  5. d Model statistics: χ2 [5] = 24.3 (p < 0.001); Nagelkerke R2 = 0.093
  6. e Model statistics: χ2 [5] = 8.4 (p = 0.14); Nagelkerke R2 = 0.03
  7. f Model statistics: χ2 [5] = 8.0 (p = 0.16); Nagelkerke R2 = 0.03