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Table 2 Clinical Characteristics Associated with Higher Persistence

From: Persistence and compliance to antidepressant treatment in patients with depression: A chart review

 

Odds Ratio (95% CI; p value)

 

Persistence to Initial Antidepressant

 

Month 1 a

Month 3 b

Month 6 c

   Sulpiride (n = 148)

1.00 (reference)

1.00 (reference)

1.00 (reference)

   Paroxetine (n = 114)

0.60

(0.34–1.06; p = 0.08)

0.61

(0.36–1.04; p = 0.07)

0.76

(0.43–1.34; p = 0.35)

   Fluvoxamine (n = 34)

0.80

(0.35–1.82; p = 0.59)

0.49

(0.21–1.12; p = 0.09)

0.59

(0.23–1.49; p = 0.27)

   Sertraline (n = 33)

1.68

(0.67–4.18; p = 0.27)

1.32

(0.60–2.91; p = 0.49)

2.59

(1.16–5.77; p = 0.02)

   Milnacipran (n = 31)

1.13

(0.47–2.71; p = 0.78)

1.40

(0.63–3.13; p = 0.41)

0.56

(0.21–1.49; p = 0.25)

   Amoxapine (n = 5)

0.00

(0.0-0.0; p = 0.99)

0.00

(0.0-0.0; p = 0.99)

0.00

(0.0-0.0; p = 0.99)

   Trazodone (n = 2)

1.13

(0.12–11.1; p = 0.92)

1.13

(0.18–7.35; p = 0.90)

0.33

(0.03–3.28; p = 0.35)

 

Persistence to Any Antidepressant

 

Month 1d

Month 3 e

Month 6 f

Sex

   

   Female (n = 197)

1.00 (reference)

1.00 (reference)

1.00 (reference)

   Male (n = 170)

2.37

(1.44–3.90; p = 0.001)

1.42

(0.93–2.17; p = 0.10)

1.29

(0.84–1.97; p = 0.24)

Age groups

   

   Before age 40 (n = 241)

1.00 (reference)

1.00 (reference)

1.00 (reference)

   40–59 (n = 95)

1.01

(0.57–1.79; p = 0.97)

1.43

(0.87–2.33; p = 0.16)

1.02

(0.62–1.66; p = 0.95)

   60 or older (n = 31)

0.70

(0.31–1.59; p = 0.40)

1.38

(0.65–2.96; p = 0.41)

1.96

(0.91–4.21; p = 0.08)

Anxiolytics use

   

   No (n = 245)

1.00 (reference)

1.00 (reference)

1.00 (reference)

   Yes (n = 122)

2.14

(1.22–3.73, p = 0.008)

1.30

(0.82–2.04, p = 0.27)

1.38

(0.87–2.17, p = 0.17)

Hypnotics use

   

   No (n = 191)

1.00 (reference)

1.00 (reference)

1.00 (reference)

   Yes (n = 176)

1.44

(0.88–2.36, p = 0.15)

1.24

(0.81–1.90, p = 0.33)

1.35

(0.87–2.17, p = 0.17)

  1. Underlined figures represent statistically significant values.
  2. a Model statistics: χ2 [11] = 36.0 (p < 0.001); Nagelkerke R2 = 0.13
  3. b Model statistics: χ2 [11] = 23.8 (p = 0.014); Nagelkerke R2 = 0.084
  4. c Model statistics: χ2 [11] = 25.8 (p = 0.007); Nagelkerke R2 = 0.095
  5. d Model statistics: χ2 [5] = 24.3 (p < 0.001); Nagelkerke R2 = 0.093
  6. e Model statistics: χ2 [5] = 8.4 (p = 0.14); Nagelkerke R2 = 0.03
  7. f Model statistics: χ2 [5] = 8.0 (p = 0.16); Nagelkerke R2 = 0.03