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Table 2 Comparisons of depot initiators and non-depot initiators on prior treatment patterns and clinical characteristics immediately preceding depot initiation

From: Treatment patterns and clinical characteristics prior to initiating depot typical antipsychotics for nonadherent schizophrenia patients

Variable

Depot Initiators (n = 39)

Non-Depot Initiators (n = 275)

Comparison P-Value

Prior treatment pattern, * n (%)

   

Use of oral typical antipsychotics

26 (66.7%)

69 (25.1%)

<.001

Use of oral atypical antipsychotics

19 (48.7%)

164 (59.6%)

.226

Use of antidepressants

11 (28.2%)

128 (46.5%)

.038

Switch/augment oral antipsychotics

17 (43.6%)

37 (13.5%)

<.001

Prior acute psychiatric services, n (%)

   

Hospitalized in 6 months prior to depot initiation

25 (64.1%)

41 (14.9%)

<.001

Multiple (≥ 2) hospitalizations between enrollment and depot initiation

14 (35.9%)

39 (14.2%)

.001

Hospitalized at or 30 days prior to depot initiation

22 (56.4%)

18 (6.5%)

<.001

Time to first hospitalization post-enrollment, mean (SD)

168.9 (140.8)

373.7 (332.5)

<.001

Emergency psychiatric services**

3 (7.7%)

25 (9.1%)

.999

Prior clinical variables, n (%)

   

Recent alcohol use**

12 (30.8%)

59 (21.5%)

.220

Recent illicit drug use**

8 (20.5%)

24 (8.7%)

.041

Recent alcohol or illicit drug use**

14 (35.9%)

66 (24.0%)

.119

Violent behavior**

3 (7.7%)

24 (8,7%)

.999

Victim of crime**

6 (16.2%)

36 (13.1%)

.608

Arrested/jailed ***

9 (23.1%)

18 (6.5%)

.002

Suicidal thought or threat**

4 (10.3%)

43 (15.6%)

.478

Suicide attempt**

0 (0)

10 (3.6%)

.619

  1. *During the 3 months prior to depot initiation (for initiators) or prior to the mean time to depot initiation (for non-depot initiators)
  2. **During the 4 weeks prior to the assessment closest to the date of depot initiation (for initiators) or prior to the mean time to depot initiation (for non-depot initiators)
  3. ***During the 6 months prior to the assessment closest to the date of depot initiation (for initiators) or prior to the mean time to depot initiation (for non-depot initiators)