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Table 2 Comparisons of depot initiators and non-depot initiators on prior treatment patterns and clinical characteristics immediately preceding depot initiation

From: Treatment patterns and clinical characteristics prior to initiating depot typical antipsychotics for nonadherent schizophrenia patients

Variable Depot Initiators (n = 39) Non-Depot Initiators (n = 275) Comparison P-Value
Prior treatment pattern, * n (%)    
Use of oral typical antipsychotics 26 (66.7%) 69 (25.1%) <.001
Use of oral atypical antipsychotics 19 (48.7%) 164 (59.6%) .226
Use of antidepressants 11 (28.2%) 128 (46.5%) .038
Switch/augment oral antipsychotics 17 (43.6%) 37 (13.5%) <.001
Prior acute psychiatric services, n (%)    
Hospitalized in 6 months prior to depot initiation 25 (64.1%) 41 (14.9%) <.001
Multiple (≥ 2) hospitalizations between enrollment and depot initiation 14 (35.9%) 39 (14.2%) .001
Hospitalized at or 30 days prior to depot initiation 22 (56.4%) 18 (6.5%) <.001
Time to first hospitalization post-enrollment, mean (SD) 168.9 (140.8) 373.7 (332.5) <.001
Emergency psychiatric services** 3 (7.7%) 25 (9.1%) .999
Prior clinical variables, n (%)    
Recent alcohol use** 12 (30.8%) 59 (21.5%) .220
Recent illicit drug use** 8 (20.5%) 24 (8.7%) .041
Recent alcohol or illicit drug use** 14 (35.9%) 66 (24.0%) .119
Violent behavior** 3 (7.7%) 24 (8,7%) .999
Victim of crime** 6 (16.2%) 36 (13.1%) .608
Arrested/jailed *** 9 (23.1%) 18 (6.5%) .002
Suicidal thought or threat** 4 (10.3%) 43 (15.6%) .478
Suicide attempt** 0 (0) 10 (3.6%) .619
  1. *During the 3 months prior to depot initiation (for initiators) or prior to the mean time to depot initiation (for non-depot initiators)
  2. **During the 4 weeks prior to the assessment closest to the date of depot initiation (for initiators) or prior to the mean time to depot initiation (for non-depot initiators)
  3. ***During the 6 months prior to the assessment closest to the date of depot initiation (for initiators) or prior to the mean time to depot initiation (for non-depot initiators)