Clinical and economic ramifications of switching antipsychotics in the treatment of schizophrenia

BMC Psychiatry

Table 2 Annual acute-care service use^a for switchers and continuers on the initial antipsychotic

	Patients continuing with their initial antipsychotics (N = 376)	Patients switching antipsychotics (N = 156)	p-value
Total Days in Study	110,482	52,288
Mean Days in Study per patient, days	293.8	335.2
Hospitalization
% of patients	16.0	26.3	<.001
Duration, days	1215	996
Rate^b	1.10%	1.90%	.014
Number of hospital admissions	115	78
Rate^c	0.11%	0.15%	.013
Partial hospitalization/day treatment centers
% of patients	10.6	18.0	.054
Duration, days	3,657	1,561
Rate^b	3.35%	3.04%	.491
	*Patients continuing with their initial antipsychotics (N = 376)*	*Patients switching antipsychotics (N = 156)*	p-value
Number of admissions to partial hospitals/day treatment centers	65	45
Rate^c	0.06%	0.09%	.306
Crisis service
% of patients	12.0	18.0	<.001
Number of admissions	78	97
Rate^b	0.07%	0.20%	.011
Any acute-care service
% of patients	28.5	42.3	<.001
Number of admissions	258	220
Rate^c	0.24%	0.44%	<.001

p values based on propensity score adjusted bootstrap resampling.
^aExcluding patients with any crisis event at baseline.
^bRate = number of days with each service divided by the total number of days in the study.
^cRate = number of admissions divided by the total number of days of treatment
Note: the denominator for the rate of partial hospitalization/day treatment days excludes hospitalization days. The denominator for the rate of crisis days excludes hospitalization and partial hospitalization/day treatment days. The denominator for admissions also excludes non-admission hospitalizations and partial hospital/day treatment days.

ISSN: 1471-244X